From: Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing
Reference | Effect | Children treated/control children (n) | Proven RSV infection (n) | Corticosteroid or other drug therapy | Duration of follow-up | Comments |
---|---|---|---|---|---|---|
[43] | Positive | 68/120 | All | Salbutamol, epinephrine, betamethasone, terbutaline, budesonide | 24 months | Group 2 (86% received corticosteroids after discharge) versus group 1 (13% with persistent symptoms received drug after discharge) |
[44] | Positive | 40/41 | All | Budesonide for 1 week or 8 weeks | 2 years | Fewer patients in 1-week group (18%) and 8-week group (12%) had asthma versus control group (37%; P < 0.02) |
[45] | Positive | Cromolyn 34; budesonide 34; controls 32 | 21 | Budesonide; cromolyn sodium | 16 weeks | Fewer wheezing episodes in last 8 weeks (cromolyn 19%, budesonide 16%, controls 47%; P < 0.05) |
[46] | Positive | 20/21 | Not identified | Beclomethasone dipropionate | 12 weeks | Wheezing (P = 0.005) and sleep patterns (P < 0.005) significantly improved in treated group at 6 weeks |
[47] | None | 83/82 | All | Budesonide | 12 months | No differences in duration of hospital admission, time to become symptom free, readmission rates, general practitioner consultation rates, or use of antiwheeze medication during follow up |
[48] | None | Cromolyn 29; budesonide 31; controls 29 | 23 | Budesonide; cromolyn sodium | 3 years | Therapy for 4 months did not affect occurrence of asthma at 3 years |
[49] | None | 27/27 | All | Prednisolone | 3–7 years | No difference in number of wheezers by age 5 years |
[50] | None | 26/28 | 35 | Budesonide | 12 months | No difference in hospital admissions or increase in symptoms at 1 year |
[51] | None | 20/18 | 50% in each group | Prednisone | 2 years | Similar prevalence of chronic respiratory symptoms at 2 years |
[52] | None | 21/19 | 83% | Budesonide | 6 months | No difference in prevalence of wheeze, cough/wheeze scores, or bronchodilator use |