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Table 1 Effect of corticosteroids on recurrent wheezing

From: Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing

Reference Effect Children treated/control children (n) Proven RSV infection (n) Corticosteroid or other drug therapy Duration of follow-up Comments
[43] Positive 68/120 All Salbutamol, epinephrine, betamethasone, terbutaline, budesonide 24 months Group 2 (86% received corticosteroids after discharge) versus group 1 (13% with persistent symptoms received drug after discharge)
[44] Positive 40/41 All Budesonide for 1 week or 8 weeks 2 years Fewer patients in 1-week group (18%) and 8-week group (12%) had asthma versus control group (37%; P < 0.02)
[45] Positive Cromolyn 34; budesonide 34; controls 32 21 Budesonide; cromolyn sodium 16 weeks Fewer wheezing episodes in last 8 weeks (cromolyn 19%, budesonide 16%, controls 47%; P < 0.05)
[46] Positive 20/21 Not identified Beclomethasone dipropionate 12 weeks Wheezing (P = 0.005) and sleep patterns (P < 0.005) significantly improved in treated group at 6 weeks
[47] None 83/82 All Budesonide 12 months No differences in duration of hospital admission, time to become symptom free, readmission rates, general practitioner consultation rates, or use of antiwheeze medication during follow up
[48] None Cromolyn 29; budesonide 31; controls 29 23 Budesonide; cromolyn sodium 3 years Therapy for 4 months did not affect occurrence of asthma at 3 years
[49] None 27/27 All Prednisolone 3–7 years No difference in number of wheezers by age 5 years
[50] None 26/28 35 Budesonide 12 months No difference in hospital admissions or increase in symptoms at 1 year
[51] None 20/18 50% in each group Prednisone 2 years Similar prevalence of chronic respiratory symptoms at 2 years
[52] None 21/19 83% Budesonide 6 months No difference in prevalence of wheeze, cough/wheeze scores, or bronchodilator use
  1. RSV, respiratory syncytial virus.