Table 1 Selected genes in which polymorphic variation could contribute to variability in treatment response in asthma (adapted from [39])
Gene | Chromosomal location | Potential treatment response affected |
|---|---|---|
β2-adrenoceptor (ADBR2) | 5q31.32 | β2-agonists (e.g. salbutamol, salmeterol) |
5-LOX (ALOX5) | 10q11.12 | 5-LOX inhibitors (e.g. zileuton), CysLT1 antagonists (e.g. zafirlukast |
M2 receptor (CHRM2) | 7q35.36 | Muscarinic antagonists (e.g. ipratropium bromide) |
M3 receptor (CHRM3) | 1q43.44 | Muscarinic antagonists (e.g. ipratropium bromide) |
GR (GRL) | 5q.31 | Glucocorticoids (e.g. prednisolone, Beclomethasone) |
PDE4A (PDE4A) | 19p13.2 | Theophylline |
PDE4D (PDE4D) | 5q12 | Theophylline |
CYP450 | Various | Montelukast, salmeterol, budesonide, Theophylline |