- Paper Report
- Open Access
Cytokines, septic shock and superoxide
- Undurti Das1
© Biomed Central Ltd 2001
- Received: 21 February 2001
- Published: 18 September 2001
- Cytokines, septic shock, SOD, superoxide
Although this paper was published some time ago, it is worth highlighting because it suggests new treatments for septicemia and septic shock. A major feature of septic shock is the development of hypotension and nonresponsiveness to sympathetic vasoconstrictor agents. The authors proposed that superoxide anions play a major role in the pathogenesis of this hemodynamic instability and organ dysfunction in septic shock. Hence, they studied the interaction between superoxide anions and catecholamines.
The authors showed that superoxide anions react with and inactivate catecholamines. This inactivation results in hyporeactivity to exogenous catecholamines. Removal of excess superoxide anions by administration of M40403 (a superoxide dimutase [SOD] mimetic) to a rat model of septic shock restored the vasopressor responses to norepinephrine and reversed the hypotension. In addition, plasma concentrations of both epinephrine and norepinephrine were significantly higher in septic rats treated with the SOD mimetic compared with untreated rats. It was also suggested that, as both epinephrine and norepinephrine inhibit the release of proinflammatory cytokines such as tumor necrosis factor-a and interleukin (IL)-1 and potentiate the release of anti-inflammatory cytokines such as IL-10, preserving the plasma levels of catecholamines is important in septic shock.
Srague-Dawley rats, HPLC