- Paper Report
- Open Access
Endotoxin in dust and bronchial asthma
- Undurti Das1
© Biomed Central Ltd 2001
- Received: 26 April 2001
- Published: 14 September 2001
- Asthma, endotoxin, Th2 responses
It is known that endotoxin present in house dust can not only cause but also increase the severity of asthma in both children and adults. Childhood asthma has been significantly associated with dust-based endotoxin in two situations: when wheezing episodes continued through age 3 or 4, and when wheezing began at age 3 or 4. In this study, a possible association between exposure to house dust endotoxin within the first 3 months after birth and wheezing during the first year of life was investigated in children with a familial predisposition to asthma or allergy.
Elevated endotoxin exposure was associated with a significantly increased risk of repeated wheeze. Presence of a dog in the home was found to be strongly associated with measured endotoxin in family room dust. Based on these studies it was suggested that presence of a dog is an important contributor to increased endotoxin levels in house dust, and that elevated endotoxin levels in house dust may increase the risk of wheezing in the first year of life.
Endotoxin measurement by kinetic Limulus assay