|  |  | Emax (mN) | pEC50 | ||||
---|---|---|---|---|---|---|---|---|
Group | dose (mg/kg) | n | Potassium | Carbachol | Endothelin-1 | Potassium | Carbachol | Endothelin-1 |
Fresh air | - | 7 | 3.56 ± 0.41†| 7.01 ± 0.09†| 3.34 ± 0.03†| 1.73 ± 0.08 | 6.30 ± 0.01†| 7.87 ± 0.01†|
Smoke | - | 7 | 5.51 ± 0.46 | 10.87 ± 0.09 | 5.53 ± 0.04 | 2.00 ± 0.18 | 6.39 ± 0.01 | 7.97 ± 0.01 |
Dex | 0.3 | 6 | 3.50 ± 0.45†| 8.75 ± 0.13†| 3.94 ± 0.06‡ | 2.02 ± 0.15 | 6.41 ± 0.02 | 7.82 ± 0.02 |
Dex | 1.0 | 6 | 3.94 ± 0.52* | 8.38 ± 0.11†+ | 4.06 ± 0.14†| 1.98 ± 0.13 | 6.40 ± 0.02 | 7.77 ± 0.04 |
GW5074 | 0.5 | 6 | 4.17 ± 0.66 | 8.27 ± 0.10†| 4.12 ± 0.06†| 1.81 ± 0.10 | 6.41 ± 0.02 | 7.80 ± 0.02 |
GW5074 | 2.0 | 6 | 3.99 ± 0.37* | 7.92 ± 0.11†+ | 3.42 ± 0.04†# | 1.93 ± 0.09 | 6.44 ± 0.02 | 7.83 ± 0.01 |