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Table 1 The Emax and pEC50 of the concentration-contractile curves of the trachea segments isolated from the sidestream smoke-exposed mice induced by potassium chloride, carbachol and endothelin-1

From: The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice

   

Emax (mN)

pEC50

Group

dose (mg/kg)

n

Potassium

Carbachol

Endothelin-1

Potassium

Carbachol

Endothelin-1

Fresh air

-

7

3.56 ± 0.41†

7.01 ± 0.09†

3.34 ± 0.03†

1.73 ± 0.08

6.30 ± 0.01†

7.87 ± 0.01†

Smoke

-

7

5.51 ± 0.46

10.87 ± 0.09

5.53 ± 0.04

2.00 ± 0.18

6.39 ± 0.01

7.97 ± 0.01

Dex

0.3

6

3.50 ± 0.45†

8.75 ± 0.13†

3.94 ± 0.06‡

2.02 ± 0.15

6.41 ± 0.02

7.82 ± 0.02

Dex

1.0

6

3.94 ± 0.52*

8.38 ± 0.11†+

4.06 ± 0.14†

1.98 ± 0.13

6.40 ± 0.02

7.77 ± 0.04

GW5074

0.5

6

4.17 ± 0.66

8.27 ± 0.10†

4.12 ± 0.06†

1.81 ± 0.10

6.41 ± 0.02

7.80 ± 0.02

GW5074

2.0

6

3.99 ± 0.37*

7.92 ± 0.11†+

3.42 ± 0.04†#

1.93 ± 0.09

6.44 ± 0.02

7.83 ± 0.01

  1. Data are expressed as the means (SEM). * p < 0.05, † p < 0.01, compared with the sidestream smoke-exposed group; + p < 0.05, # p < 0.01 compared with the low dosage group. Emax, maximal contraction; pEC50, negative logarithm of the agonist concentration that produces 50% of the maximal effect; Dex, dexamethasone.