Figure 4

Effect of dexamethasone and GW5074 on the tracheal pathology of mice exposed to passive smoke. Hematoxylin and eosin-stained tracheal tissue derived from six groups of mice: fresh air group, passive smoke-exposed group, dexamethasone (0.3 mg/kg, 1 mg/kg) plus passive smoke-exposed groups and GW5074 (0.5 mg/kg, 2 mg/kg) plus passive smoke-exposed groups. Inflammatory cells and tracheal mucous gland hypertrophy were not found in the fresh air group (A1: ×100 and A2: ×400). There were many infiltrated inflammatory cells and mucous gland hypertrophy in the tracheas of the passive smoke-exposed group (B1: ×100 and B2: ×400). The infiltration of inflammatory cells and tracheal mucous gland hypertrophy were decreased in both the 1 mg/kg (C1: ×100 and C2: ×400) and the 0.3 mg/kg (D1: ×100 and D2: ×400) dexamethasone groups and both the 2 mg/kg (E1: ×100 and E2: ×400) and the 0.5 mg/kg (F1: ×100 and F2: ×400) GW5074 groups, compared with the passive smoke-exposed group.