Respiratory Research

Table 2 Sensitivity of different influenza strains to inhibition by SP-D and their HA glycan attachments

From: Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D

H3N2	SPD	63	81	122	126	133	144	165	246	276
X31 (Aichi/68xA/PR8)	>2 μg		+					+
A/Udorn/72	>2 μg		+					+
A/Shandong/9/93	>2 μg	+			+			+	+	+
A/Wuhan/359/95	>2 μg	+			+			+	+
A/Sydney/5/97	62 ng	+		+	+	+		+	+
A/Panama/2007/99	7.8 ng	+		+	+	+	+	+	+
A/Fujian/411/02 (rg)	3.9 ng	+		+	+	+	+	+	+
*Sialic acid distance* (Å)		23	28	20	18	7.6	9.8	20	19	43
H1N1	SPD	71	104	142	144	172	177
A/Puerto Rico/8/34	>2 μg
A/Memphis/10/78	3.9 ng		+		+	+	+
A/Memphis/7/80	7.8 ng		+		+	+	+
A/Memphis/14/96	1 μg	+	+	+			+
A/New Caledonia/20/99	>2 μg	+	+	+			+
A/Memphis/6/2001	1 μg	+	+	+			+
*Sialic acid distance* (Å)		21	17	15	9	13	24
H1N1	SPD	170	181
A/HK/213/03	2 μg		+
A/Vietnam/1203/04	>2 μg	+	+
*Sialic acid distance* (Å)		15	27

Notes:
1. SPD masses refer to amount required in hemagglutination inhibition assay to inhibit influenza-mediated agglutination of chicken and turkey red blood cells.
2. Numbers refer to amino acid number in the influenza HA "head"; "+" indicates potential N-linked glycosylation site based on sequence. Bold numbers indicate residues with large apparent influence on interaction of virus with SP-D

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