Table 2
From: Association of mast cells with lung function in chronic obstructive pulmonary disease
a. The concentration of tryptase positive mast cells (MC-T) per region for patients with COPD and controls | ||
|---|---|---|
Controls (n = 10) | COPD (n = 19) | |
Central airways | ||
Epithelium (cells/mm) | 0.07 [0.0–0.9] | 0.0 [0.0–0.1] |
Subepithelial area (cells/mm2) | 108.8 [83.9–190.2] | 53.7 [25.7–120.8]¶ |
Airway smooth muscle (cells/mm2) | 32.5 [15.8–49.9] | 20.1 [10.5–33.3] |
% degranulated mast cells | 35.9 [21.9–51.2] | 28.0 [22.4–37.4] |
Peripheral airways | ||
Epithelium (cells/mm) | 0.0 [0.0–0.9] | 0.0 [0.0–0.2] |
Subepithelial area (cells/mm2) | 247.9 [73.9–548.2] | 184.6 [100.4–282.3] |
Airway smooth muscle (cells/mm2) | 12.6 [0.0–36.9] | 18.4 [0.0–47.6] |
Adventitia (cells/mm2) | 279.4 [79.2–646.9] | 214.9 [107.2–327.2] |
% degranulated mast cells | 68.6 [41.5–81.4] | 67.5 [53.0–84.1] |
b. The concentration of chymase positive mast cells (MC-C) per region for patients with COPD and controls | ||
|---|---|---|
Controls (n = 10) | COPD (n = 19) | |
Central airway samples | ||
Epithelium (cells/mm) | 0.0 [0.0–0.0] | 0.0 [0.0–0.3]¶¶ |
Subepithelial area (cells/mm2) | 18.1 [8.2–28.9] | 11.0 [4.5–28.3] |
Airway smooth muscle (cells/mm2) | 10.6 [2.7–15.2] | 3.5 [0.0–6.0] |
% degranulated mast cells | 33.3 [25.7–52.2] | 40.0 [26.8–58.3] |
Peripheral airways | ||
Epithelium (cells/mm) | 0.0 [0.0–0.0] | 0.0 [0.0–0.2] |
Subepithelial area (cells/mm2) | 19.4 [0.0–71.8] | 54.5 [0.0–160.0] |
Airway smooth muscle (cells/mm2) | 0.0 [0.0–54.1] | 0.0 [0.0–50.7] |
Adventitial layer (cells/mm2) | 128.0 [44.1–184.0] | 68.5 [13.2–162.7] |
% degranulated mast cells | 66.8 [55.6–93.2] | 63.9 [52.1–95.0] |