Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance

Respiratory Research

Table 1 Serum- IgE and Flow Cytometric data

2 weeks	PBS/Air	PBS/Smoke	OVA/Air	OVA/Smoke
OVA – IgE (U/ml)	0.97 ± 0.40	2.30 ± 0.50	14.02 ± 4.44*	20.00 ± 4.38*
Total IgE (μg/ml)	0.05 ± 0.01	0.09 ± 0.02	0.52 ± 0.37*	0.56 ± 0.25*
Lung dendritic cells (perc.)	0.94 ± 0.06	1.41 ± 0.07*	1.74 ± 0.16*	1.90 ± 0.23*
Lung CD4 ⁺ CD69 ⁺ T cells (perc. of T cells)	7.00 ± 1.09	9.69 ± 0.74*	13.88 ± 1.29*	18.52 ± 2.04*^#
Lung CD86 ⁺ dendritic cells (perc. of DC)	53.27 ± 2.58	59.03 ± 0.96	63.84 ± 2.84*	65.62 ± 2.18*⁺
4 weeks	PBS/Air	PBS/Smoke	OVA/Air	OVA/Smoke
OVA- IgE (U/ml)	2.75 ± 0.79	3.67 ± 0.70	35.23 ± 9.06*	55.22 ± 8.22*
Total IgE (μg/ml)	0.17 ± 0.05	0.16 ± 0.03	0.24 ± 0.068	0.33 ± 0.074
Lung dendritic cells (perc.)	1.07 ± 1.29	2.09 ± 0.13*⁺	1.33 ± 0.52	1.53 ± 0.86*
Lung CD4 ⁺ CD69 ⁺ T cells (perc. of T cells)	8.36 ± 0.90	14.29 ± 1.81*	13.57 ± 0.63*	18.16 ± 1.06*^#
Lung CD86 ⁺ DC (perc. of DC)	55.33 ± 3.22	73.21 ± 1.31*	63.07 ± 1.99	72.32 ± 1.17*^#

ISSN: 1465-993X