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Table 1 Chitinase expression in three different strains of rats infected with C. neoformans

From: Pulmonary cryptococcosis induces chitinase in the rat

 

TH bias**

BAL

LUNG

  

PBS

INFECTED

PBS

INFECTED

Fischer

1 [3,11]

1.8 ± 0.4

11.9 ± 2.6*

2.1 ± 0.3

10.6 ± 1.3*

Sprague Dawley

Outbred, Non-biased [12,20]

1.8 ± 0.5

15.2 ± 4.4*

0.7 ± .01

6.4 ± 1.0*

Brown Norway

2 [12,20]

1.9 ± 0.5

6.6 ± 3.9*

1.4 ± .03

5.1 ± 1.7*

  1. Chitinase activity (units × 10-3/ml) in different rat strains following experimental pulmonary cryptococcal infection. Values represent means ± 1 SD. For all experiments 4–5 animals were used per group and measurements done at 2 weeks. * P < 0.05 for comparison between infected tissues and PBS-inoculated controls. **TH bias of rat strain reflects tendency to develop TH1 (cellular) versus TH2 (humoral/allergic) inflammation in response to infection or antigen challenge.
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Respiratory Research

ISSN: 1465-993X

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