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Table 5 Mean (SE) FEV1 %predicted in relation to AAT quintile classes in non-current smokers†

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

  Quintile classes of AAT (g/l)
  Q0 (<0.9) Q1 (≥0.9–<1.13) Q2 (≥1.13, <1.22) Q3 (≥1.22, <1.31) Q4 (≥1.31, <1.41) Q5 (≥1.41) ptrend from model not including Q0
Men (n) 66 522 439 351 226 142  
FEV1 (% predicted), CRP adj. 99.5 (1.8) 97.6 (0.6) 97.9 (0.7) 98.2 (0.8) 97.0 (1.0) 92.9 (1.3) 0.05
FEV1 (% predicted), no CRP adj.* 99.8 (1.8) 98.1 (0.6) 98.1 (0.6) 98.0 (0.8) 96.5 (0.9) 91.9 (1.2) <0.001
Women (n) 64 289 282 403 315 395  
FEV1 (% predicted) CRP adj. 101.0 (1.8) 100.4 (0.9) 99.8 (0.9) 100.3 (0.7) 99.9 (0.8) 99.3 (0.8) 0.85
FEV1 (% predicted), no CRP adj. * 101.8 (1.8) 100.9 (0.9) 100.3 (0.9) 100.4 (0.7) 100.0 (0.8) 98.4 (0.7) 0.13
Premenopausal women (n) 27 100 109 151 131 187  
FEV1 (% predicted), CRP adj. 98.7 (2.4) 98.3 (1.3) 97.2 (1.2) 99.6 (1.0) 101.5 (1.1) 99.7 (1.0) 0.02
FEV1 (% predicted), no CRP adj.* 99.1 (2.4) 98.8 (1.3) 97.1 (1.0) 99.6 (1.0) 101.7 (1.1) 99.1 (1.0) 0.11
Postmenopausal women (n) 37 189 173 252 184 208  
FEV1 (% predicted), CRP adj. 102.5 (2.5) 101.5 (1.1) 101.5 (1.2) 100.8 (1.0) 98.8 (1.1) 98.7 (1.1) 0.04
FEV1 (% predicted), no CRP adj.* 103.4 (2.5) 102.1 (1.1) 101.7 (1.1) 101.0 (1.0) 98.7 (1.1) 97.7 (1.1) <0.001
  1. † adjusted for BMI, passive smoking, years since quitting, systolic blood pressure, alcohol consumption, study area, CRP, CRP2 (models with CRP); * adjusted for all covariates but CRP; ¶additionally adjusted for menopausal status, intake of female hormones; women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded;