Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

Respiratory Research

Table 5 Mean (SE) FEV1 %predicted in relation to AAT quintile classes in non-current smokers†

	Quintile classes of AAT (g/l)
	Q0 (<0.9)	Q1 (≥0.9–<1.13)	Q2 (≥1.13, <1.22)	Q3 (≥1.22, <1.31)	Q4 (≥1.31, <1.41)	Q5 (≥1.41)	p_trend from model not including Q0
Men (n)	66	522	439	351	226	142
FEV1 (% predicted), CRP adj.	99.5 (1.8)	97.6 (0.6)	97.9 (0.7)	98.2 (0.8)	97.0 (1.0)	92.9 (1.3)	0.05
FEV1 (% predicted), no CRP adj.*	99.8 (1.8)	98.1 (0.6)	98.1 (0.6)	98.0 (0.8)	96.5 (0.9)	91.9 (1.2)	<0.001
Women (n) ¶	64	289	282	403	315	395
FEV1 (% predicted) CRP adj.	101.0 (1.8)	100.4 (0.9)	99.8 (0.9)	100.3 (0.7)	99.9 (0.8)	99.3 (0.8)	0.85
FEV1 (% predicted), no CRP adj. *	101.8 (1.8)	100.9 (0.9)	100.3 (0.9)	100.4 (0.7)	100.0 (0.8)	98.4 (0.7)	0.13
Premenopausal women (n) ¶	27	100	109	151	131	187
FEV1 (% predicted), CRP adj.	98.7 (2.4)	98.3 (1.3)	97.2 (1.2)	99.6 (1.0)	101.5 (1.1)	99.7 (1.0)	0.02
FEV1 (% predicted), no CRP adj.*	99.1 (2.4)	98.8 (1.3)	97.1 (1.0)	99.6 (1.0)	101.7 (1.1)	99.1 (1.0)	0.11
Postmenopausal women (n) ¶	37	189	173	252	184	208
FEV1 (% predicted), CRP adj.	102.5 (2.5)	101.5 (1.1)	101.5 (1.2)	100.8 (1.0)	98.8 (1.1)	98.7 (1.1)	0.04
FEV1 (% predicted), no CRP adj.*	103.4 (2.5)	102.1 (1.1)	101.7 (1.1)	101.0 (1.0)	98.7 (1.1)	97.7 (1.1)	<0.001

† adjusted for BMI, passive smoking, years since quitting, systolic blood pressure, alcohol consumption, study area, CRP, CRP² (models with CRP); * adjusted for all covariates but CRP; ¶additionally adjusted for menopausal status, intake of female hormones; women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded;

ISSN: 1465-993X