Skip to main content

Table 5 Mean (SE) FEV1 %predicted in relation to AAT quintile classes in non-current smokers†

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

 

Quintile classes of AAT (g/l)

 

Q0 (<0.9)

Q1 (≥0.9–<1.13)

Q2 (≥1.13, <1.22)

Q3 (≥1.22, <1.31)

Q4 (≥1.31, <1.41)

Q5 (≥1.41)

ptrend from model not including Q0

Men (n)

66

522

439

351

226

142

 

FEV1 (% predicted), CRP adj.

99.5 (1.8)

97.6 (0.6)

97.9 (0.7)

98.2 (0.8)

97.0 (1.0)

92.9 (1.3)

0.05

FEV1 (% predicted), no CRP adj.*

99.8 (1.8)

98.1 (0.6)

98.1 (0.6)

98.0 (0.8)

96.5 (0.9)

91.9 (1.2)

<0.001

Women (n)

64

289

282

403

315

395

 

FEV1 (% predicted) CRP adj.

101.0 (1.8)

100.4 (0.9)

99.8 (0.9)

100.3 (0.7)

99.9 (0.8)

99.3 (0.8)

0.85

FEV1 (% predicted), no CRP adj. *

101.8 (1.8)

100.9 (0.9)

100.3 (0.9)

100.4 (0.7)

100.0 (0.8)

98.4 (0.7)

0.13

Premenopausal women (n)

27

100

109

151

131

187

 

FEV1 (% predicted), CRP adj.

98.7 (2.4)

98.3 (1.3)

97.2 (1.2)

99.6 (1.0)

101.5 (1.1)

99.7 (1.0)

0.02

FEV1 (% predicted), no CRP adj.*

99.1 (2.4)

98.8 (1.3)

97.1 (1.0)

99.6 (1.0)

101.7 (1.1)

99.1 (1.0)

0.11

Postmenopausal women (n)

37

189

173

252

184

208

 

FEV1 (% predicted), CRP adj.

102.5 (2.5)

101.5 (1.1)

101.5 (1.2)

100.8 (1.0)

98.8 (1.1)

98.7 (1.1)

0.04

FEV1 (% predicted), no CRP adj.*

103.4 (2.5)

102.1 (1.1)

101.7 (1.1)

101.0 (1.0)

98.7 (1.1)

97.7 (1.1)

<0.001

  1. † adjusted for BMI, passive smoking, years since quitting, systolic blood pressure, alcohol consumption, study area, CRP, CRP2 (models with CRP); * adjusted for all covariates but CRP; ¶additionally adjusted for menopausal status, intake of female hormones; women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded;