Skip to main content

Table 4 Mean (SE) FEV1 %predicted in relation to AAT quintile classes †

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

  Quintile classes of AAT (g/l)
  Q0 (<0.9) Q1 (≥0.9–<1.13) Q2 (≥1.13, <1.22) Q3 (≥1.22, <1.31) Q4 (≥1.31, <1.41) Q5 (≥1.41) ptrend from model not including Q0
All (n) 152 952 832 932 764 817  
FEV1 (% predicted) CRP adj. 99.8 (1.2) 98.0 (0.5) 98.3 (0.5) 98.1 (0.5) 97.6 (0.5) 96.6 (0.5) 0.28
FEV1 (% predicted), no CRP adj. * 100.4 (1.2) 98.7 (0.5) 98.7 (0.5) 98.2 (0.5) 97.4 (0.5) 95.5 (0.5) <0.001
Men (n)‡ 79 627 511 460 351 256  
FEV1 (% predicted) CRP adj. 99.0 (1.6) 96.7 (0.6) 97.3 (0.6) 97.2 (0.6) 95.8 (0.8) 93.8 (1.0) 0.08
FEV1 (% predicted), no CRP adj. * 99.3 (1.6) 97.3 (0.6) 97.6 (0.6) 97.1 (0.7) 95.4 (0.8) 92.6 (0.9) <0.001
Women (n) ¶, ‡ 73 325 321 472 413 561  
FEV1 (% predicted) CRP adj. 100.6 (1.6) 99.4 (0.8) 99.2(0.8) 99.3(0.7) 99.2 (0.7) 98.8 (0.6) 0.76
FEV1 (% predicted), no CRP adj. * 101.4 (1.7) 99.9 (0.8) 99.7(0.8) 99.5(0.7) 99.3 (0.7) 97.8 (0.6) 0.19
Never/Former Smokers (n) ¶, ‡ 130 811 721 754 541 537  
FEV1 (% predicted), CRP adj. 100.4 (1.3) 99.1 (0.5) 99.0 (0.5) 99.1 (0.5) 98.4 (0.6) 96.9 (0.7) 0.10
FEV1 (% predicted), no CRP adj.* 100.9 (1.3) 99.6 (0.5) 99.3 (0.5) 99.1 (0.5) 98.2 (0.6) 95.9 (0.7) <0.001
Current Smokers (n) ¶, ‡ 22 141 111 178 223 280  
FEV1 (% predicted), CRP adj. 96.9 (2.9) 93.6 (1.2) 95.0 (1.3) 93.8 (1.0) 94.5 (0.9) 95.6 (0.9) 0.16
FEV1 (% predicted), no CRP adj.* 97.2 (2.9) 94.3 (1.0) 95.7 (1.3) 94.3 (1.0) 94.7 (0.9) 94.5 (0.9) 0.91
Currents Smokers ≥15 cigs/d (n) ¶,‡ 11 60 48 103 122 182  
FEV1 (% predicted), CRP adj. 96.5 (4.3) 88.8 (1.9) 93.6 (2.1) 91.2 (1.4) 93.6 (1.3) 95.3 (1.1) 0.01
FEV1 (% predicted), no CRP adj.* 96.7 (4.3) 89.7 (1.9) 94.4 (1.1) 91.2 (1.4) 93.9 (1.3) 94.4 (1.1) 0.06
Currents Smokers <15 cigs/d (n) ¶,‡ 11 81 63 75 101 98  
FEV1 (% predicted), CRP adj. 99.6 (3.9) 98.3 (1.5) 96.9 (1.7) 96.6 (1.5) 95.8 (1.3) 94.9 (1.5) 0.21
FEV1 (% predicted), no CRP adj.* 99.9 (3.9) 98.9 (1.5) 97.6 (1.4) 97.2 (1.5) 95.9 (1.3) 93.5 (1.4) 0.02
  1. † adjusted for gender, smoking status (never, former, current), years since quitting in former smokers, cigarettes/day in current smokers, passive smoking in never smokers, BMI, systolic blood pressure, alcohol consumption, study area, menopausal status in women, intake of female hormones in women, CRP, CRP2 (models with CRP adjustment); * adjusted for all covariates but CRP; ¶women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded from the analysis; ‡ P-values for interactions: In All: AAT*gender: p = 0.02(CRP adj); p = 0.007(no CRP adj.); In women: AAT*menopausal status: 0.01 (CRP adj.); 0.008 no CRP adj.); AAT*intake female hormones: p > 0.80, irrespective of menopausal status; AAT*smoking (heavy current smoking vs. all others): all men: p = 0.02 (CRP adj.); p = 0.03 (no CRP adj.); all women: p = 0.11 (CRP adj.); p = 0.11 (no CRP adj.); postmenopausal women: p = 0.08 (CRP adj.); p = 0.07 (no CRP adj.); premenopausal women: p = 0.59 (CRP adj.); p = 0.58 (no CRP adj.)