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Table 4 Mean (SE) FEV1 %predicted in relation to AAT quintile classes †

From: Circulating alpha1-antitrypsin in the general population: Determinants and association with lung function

 

Quintile classes of AAT (g/l)

 

Q0 (<0.9)

Q1 (≥0.9–<1.13)

Q2 (≥1.13, <1.22)

Q3 (≥1.22, <1.31)

Q4 (≥1.31, <1.41)

Q5 (≥1.41)

ptrend from model not including Q0

All (n)

152

952

832

932

764

817

 

FEV1 (% predicted) CRP adj.

99.8 (1.2)

98.0 (0.5)

98.3 (0.5)

98.1 (0.5)

97.6 (0.5)

96.6 (0.5)

0.28

FEV1 (% predicted), no CRP adj. *

100.4 (1.2)

98.7 (0.5)

98.7 (0.5)

98.2 (0.5)

97.4 (0.5)

95.5 (0.5)

<0.001

Men (n)‡

79

627

511

460

351

256

 

FEV1 (% predicted) CRP adj.

99.0 (1.6)

96.7 (0.6)

97.3 (0.6)

97.2 (0.6)

95.8 (0.8)

93.8 (1.0)

0.08

FEV1 (% predicted), no CRP adj. *

99.3 (1.6)

97.3 (0.6)

97.6 (0.6)

97.1 (0.7)

95.4 (0.8)

92.6 (0.9)

<0.001

Women (n) ¶, ‡

73

325

321

472

413

561

 

FEV1 (% predicted) CRP adj.

100.6 (1.6)

99.4 (0.8)

99.2(0.8)

99.3(0.7)

99.2 (0.7)

98.8 (0.6)

0.76

FEV1 (% predicted), no CRP adj. *

101.4 (1.7)

99.9 (0.8)

99.7(0.8)

99.5(0.7)

99.3 (0.7)

97.8 (0.6)

0.19

Never/Former Smokers (n) ¶, ‡

130

811

721

754

541

537

 

FEV1 (% predicted), CRP adj.

100.4 (1.3)

99.1 (0.5)

99.0 (0.5)

99.1 (0.5)

98.4 (0.6)

96.9 (0.7)

0.10

FEV1 (% predicted), no CRP adj.*

100.9 (1.3)

99.6 (0.5)

99.3 (0.5)

99.1 (0.5)

98.2 (0.6)

95.9 (0.7)

<0.001

Current Smokers (n) ¶, ‡

22

141

111

178

223

280

 

FEV1 (% predicted), CRP adj.

96.9 (2.9)

93.6 (1.2)

95.0 (1.3)

93.8 (1.0)

94.5 (0.9)

95.6 (0.9)

0.16

FEV1 (% predicted), no CRP adj.*

97.2 (2.9)

94.3 (1.0)

95.7 (1.3)

94.3 (1.0)

94.7 (0.9)

94.5 (0.9)

0.91

Currents Smokers ≥15 cigs/d (n) ¶,‡

11

60

48

103

122

182

 

FEV1 (% predicted), CRP adj.

96.5 (4.3)

88.8 (1.9)

93.6 (2.1)

91.2 (1.4)

93.6 (1.3)

95.3 (1.1)

0.01

FEV1 (% predicted), no CRP adj.*

96.7 (4.3)

89.7 (1.9)

94.4 (1.1)

91.2 (1.4)

93.9 (1.3)

94.4 (1.1)

0.06

Currents Smokers <15 cigs/d (n) ¶,‡

11

81

63

75

101

98

 

FEV1 (% predicted), CRP adj.

99.6 (3.9)

98.3 (1.5)

96.9 (1.7)

96.6 (1.5)

95.8 (1.3)

94.9 (1.5)

0.21

FEV1 (% predicted), no CRP adj.*

99.9 (3.9)

98.9 (1.5)

97.6 (1.4)

97.2 (1.5)

95.9 (1.3)

93.5 (1.4)

0.02

  1. † adjusted for gender, smoking status (never, former, current), years since quitting in former smokers, cigarettes/day in current smokers, passive smoking in never smokers, BMI, systolic blood pressure, alcohol consumption, study area, menopausal status in women, intake of female hormones in women, CRP, CRP2 (models with CRP adjustment); * adjusted for all covariates but CRP; ¶women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded from the analysis; ‡ P-values for interactions: In All: AAT*gender: p = 0.02(CRP adj); p = 0.007(no CRP adj.); In women: AAT*menopausal status: 0.01 (CRP adj.); 0.008 no CRP adj.); AAT*intake female hormones: p > 0.80, irrespective of menopausal status; AAT*smoking (heavy current smoking vs. all others): all men: p = 0.02 (CRP adj.); p = 0.03 (no CRP adj.); all women: p = 0.11 (CRP adj.); p = 0.11 (no CRP adj.); postmenopausal women: p = 0.08 (CRP adj.); p = 0.07 (no CRP adj.); premenopausal women: p = 0.59 (CRP adj.); p = 0.58 (no CRP adj.)
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Respiratory Research

ISSN: 1465-993X

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