Figure 8

Micrographs showing nasal mucosal neutrophils and eosinophils 24 hours post TNFα and sham challenge. A: Sham-challenged healthy subject: biopsy stained for the neutrophil granule protein MPO. B: TNFα challenged patient with allergic rhinitis: biopsy stained for MPO. C: Sham-challenged healthy subject: biopsy stained for the eosinophil granule protein ECP. D: TNFα challenged healthy subject: biopsy stained for ECP. Nasal biopsy numbers of neutrophils were increased 24 hours after TNFα challenge.