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Table 3 Inhibition of IFN-γ secretion in co-cultures. The effects of 100 nM p38 inhibitor BIRB-796, 100 nM beclomethasone, 500 nM IKK-2 inhibitor V, 100 nM PDE4 inhibitor rolipram, 1 μM PI3 kinase inhibitor and human 10 μg/ml CD40 antibody on secretion of IP-10 from co-cultures.

From: The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures

 

A549/PBMC + IL-12

BIRB-796

99 (± 0) ***

IKK-2 inh. V

11 (± 9)

Beclomet

98 (± 0) ***

Rolipram

26 (± 7)

PI3 kin. Inh.

77 (± 7)*

CD40 ab

26 (± 11)

  1. Data represents the percentage of inhibition, mean (SEM). ***p < 0.001 and *p < 0.05, ANOVA with Bonferroni's multiple comparison test.