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Figure 2 | Respiratory Research

Figure 2

From: Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses

Figure 2

Lectin binding to upper and lower respiratory tract. Tissue distribution of Sambucus nigra agglutinin (SNA) for SAα2,6, Maackia amurensis agglutinin 1 (MAA1), and Maackia amurensis agglutinin 2 (MAA2) for SAα2,3 binding in the adult and paediatric respiratory tract. Serial sections of nasopharynx (A-C), adult bronchus (D-F), adult lung (G-I), paediatric bronchus (J-L), and paediatric lung (M-O) are shown and stained with SNA (A,D,G,J,M), MAA1 (B,E,H,K,N) and MAA2 (C,F,I,L,O). The adult nasopharynx shows SNA and MAA1 binding in the epithelium but no MAA2 binding. A similar pattern is also present in the adult bronchus and in addition the pneumocytes show MAA1 and MAA2 binding (E,F). Alveolar macrophages (G-I) demonstrate minimal SNA and no MAA2 binding but are positive for MAA1. The paediatric bronchus shows a greater binding of the epithelium with MAA1 (K) than the adult (E). The pneumocytes (M) also show more SNA binding than the adult (G). Staining using HRP conjugated SNA and biotin conjugated MAA1 and MAA2. (A-F) and (J-L) at 200 × magnification and (G-I) and (M-O) at 400 × magnification.

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Respiratory Research

ISSN: 1465-993X

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