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Table 3 Pros and cons of noninvasive tidal midexpiratory flow measurement

From: Invasive and noninvasive methods for studying pulmonary function in mice

pros cons
• based on physiological principles • underestimation of the magnitude of airway responsiveness as compared with direct measures of pulmonary mechanics
• acceptable agreement with simultaneous invasive measurements of pulmonary mechanics • restraint by neck collar
• physical meaning enables comparability of data from animal to animal