Figure 5

Comparison of concentrations of fluticasone furoate (FF), fluticasone propionate (FP) and mometasone furoate (MF) in human lung tissue. The columns represent the mean and mean deviation of the mean from four independent experiments. The left columns represent the compound concentration in tissue before incubation in human plasma. This tissue binding of FF was statistically significantly higher compared to FP (p ≤ 0.001) and MF (p ≤ 0.01). The right columns display the glucocorticoid concentrations remaining in the lung tissue after one hour equilibration with human plasma at 37°C. Remaining concentrations of FP and FF were not different while statistically significantly lower concentrations of MF were retained in the tissue compared to FF (p ≤ 0.01) and FP (p ≤ 0.001).