Figure 2

Relationship between the relative receptor affinities (RRA) of glucocorticoids and their lipophilicity expressed as relative retention times (k'). The reference glucocorticoid was dexamethasone for RRA and dexamethasone-21-isonicotinate for k'. Coefficient of correlation was r = 0.982 and the correlation was statistically significant (p ≤ 0.0001). Symbols used: filled black squares: glucocorticoids without ester function at C21 open white circles: glucocorticoids esterified at C21. * RRA determined in our own experiments, all other RRAs were obtained from [5, 16]. Abbreviations: Amcinonide (Amci), Dexamethasone (Dexa), Dexamethasone-21-isonicotinate (21-DIN), Flunisolide (Fluni), Fluticasone propionate (FP), Fluticasone furoate (FF), Mometasone (M), 6β-Hydroxy-Mometasone furoate (6OH-MF), Mometasone furoate (MF), Budesonide (Bud), Ciclesonide (Cicle), desisobutyryl Ciclesonide (des-Cicle), Beclomethasone-17,21-dipropionate (BDP), Beclomethasone-17-monopropionate (17-BMP), Beclomethasone-21-monopropionate (21-BMP), Prednisolone-21-propionate (21-PP).