Table 1 Cytokines and chemokines in lung homogenates.
From: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
Cytokines/Chemokines | Values in pg/g lung homogenate (mean (SD)) | P-values | |||||
|---|---|---|---|---|---|---|---|
|  | WT-NSm | WT-Sm | TKO-NSm | TKO-Sm | Smoke × Genotype interaction | Smoke effect | Genotype effect |
IL-1α | 118.4 (38.1) | 195.3 (42.8) | 120.8 (22.0) | 158.6 (40.8) | NS | 0.00 ↑ | NS |
IL-1β | 54.0 (10.6) | 61.5 (12.8) | 50.4 (6.6) | 51.7 (6.6) | NS | NS | NS |
IL-2 | 87.9 (35.9) | 80.3 (20.3) | 70.8 (13.3) | 80.3 (23.5) | NS | NS | NS |
IL-4 | 4.5 (0.8) | 5.0 (0.6) | 4.1 (0.6) | 4.7 (0.7) | NS | NS | NS |
IL-5 | 23.6 (3.8) | 24.4 (7.1) | 22.7 (3.6) | 23.9 (6.6) | NS | NS | NS |
IL-6 | 45.4 (11.6) | 111.7 (58.0) | 47.5 (6.0) | 76.0 (17.7) | NS | 0.01 ↑ | NS |
IL-7 | 192.1 (26.4) | 196.2 (28.0) | 162.0 (9.8) | 183.2 (24.4) | NS | NS | 0.05 ↓ |
IL-8 (KC) | 147.1 (58.2) | 755.2 (448.0) | 133.1 (41.1) | 291.8 (93.7) | 0.05 ↓ | 0.01 ↑ | 0.01 ↓ |
IL-9 | 136.3 (38.4) | 123.6 (21.0) | 111.3 (25.1) | 107.9 (14.5) | NS | NS | NS |
IL-10 | 359.6 (124.4) | 359.4 (103.9) | 384.4 (186.4) | 366.9 (48.4) | NS | NS | NS |
IL-12p70 | 213.9 (30.7) | 213.6 (30.6) | 173.9 (15.5) | 198.9 (21.0) | NS | NS | 0.03 ↓ |
IL-13 | 40.3 (5.3) | 49.8 (13.8) | 36.8 (2.7) | 45.9 (7.5) | NS | 0.02 ↑ | NS |
IL-15 | 99.0 (21.7) | 108.0 (15.8) | 84.9 (7.4) | 98.2 (11.9) | NS | NS | NS |
IL-17 | 20.4 (2.5) | 34.2 (16.3) | 17.6 (1.4) | 20.8 (1.8) | NS | 0.05 ↑ | 0.04 ↓ |
TNFα | 14.2 (2.4) | 17.7 (2.9) | 11.8 (1.9) | 13.8 (1.4) | NS | 0.01 ↑ | 0.00 ↓ |
IFNγ | 80.5 (24.4) | 73.11 (14.6) | 80.0 (25.4) | 78.3 (12.6) | NS | NS | NS |
G-CSF | 24.9 (3.2) | 51.3 (24.8) | 21.5 (4.7) | 27.5 (2.1) | 0.10 ↓ | 0.02 ↑ | 0.03 ↓ |
GM-CSF | 36.2 (5.7) | 40.5 (5.4) | 30.1 (1.4) | 35.4 (5.7) | NS | 0.03 ↑ | 0.01 ↓ |
IP-10 | 297.8 (116.5) | 431.9 (304.5) | 232.9 (108.4) | 220.7 (74.1) | NS | NS | NS |
MCP-1 | 38.0 (2.4) | 46.9 (7.2) | 29.1 (2.0) | 48.2 (24.2) | NS | 0.02 ↑ | NS |
MIP1α | 600.1 (46.4) | 657.3 (83.7) | 491.3 (42.9) | 516.0 (82.1) | NS | NS | 0.00 ↓ |
RANTES | 37.4 (8.7) | 50.3 (38.0) | 57.1 (43.9) | 33.9 (11.4) | NS | NS | NS |