Figure 4
From: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
Emphysema measurement with the Lmi method in mice that were exposed to cigarette smoke or air for 6 months. Paraffin sections were stained with H&E and digital images (19 to 32 images per lung) were morphometrically analyzed. No significant differences were measured between the four groups, although a slight increase in airspace size was detected in both WT and TKO mice that were exposed to smoke. WT: Wild-type; TKO: Mrp1/Mdr1a/1b triple knock-out; Sm: smoker; NSm: non-smoker; Lmi: mean linear intercept.