Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin

Table 1 Increased protein expression profiles

Protein Identified	Accession #	M_r/D	pl	Magnitutde of expression change					0.96 hr CV%	Protein score
				0.24 hr	0.24 hr CV%	24.96	24.96 hr CV%	0.96
Parkinson disease prot.7/Drosophila prot. J-1 PARK-7/DJ-1	gi\|16924002	19961.4	6.32	30.05*	0.03	0.34	0.03	10.19*	0.03	108
Annexin V	gi\|1421099	10028.3	5.3	27.00*	0.12	0.48	0.03	13.02*	0.02	312
Rat tumor suppressor p30/Hyaluronic acid binding protein 1 homologue HABP-1	gi\|34097946	61034.1	6.2	15.02*	0.05	0.73	0.05	11.00*	0.05	77
Heat shock protein k71 mutant w ATpase	gi\|1943516	41866.6	6.36	6.44*	0.03	0.5	0.02	3.24*	0.03	92
Annexin VI	gi\|13994159	75706.5	6.39	6.22*	0.02	0.5	0.02	3.10*	0.01	313
Septin 2	gi\|16924010	41566.3	6.15	4.19*	0.02	0.24	0.02	1.00	0.02	118
Capping G protein	gi\|18605629	38744.7	6.47	4.18*	0.02	0.24	0.03	1.00	0.02	375
Actin related protein 3 Actr-3	gi\|34879484	55252.4	6.55	4.14*	0.02	0.5	0.02	2.07*	0.01	310
Proteosome 28 subunit(PA28)/Interferon gamma inducible protein (IGIP)	gi\|8394088	28559.1	5.77	3.98*	0.01	0.62	0.03	2.48*	0.02	228
Moesin	gi\|13540689	6769.8	6.16	3.12*	0.01	0.46	0.01	144	0.01	496
Rho GDP dissociation inhibitor (Rho-GDI)	gi\|56541074	23392.8	6.12	2.93*	0.02	0.47	0.01	1.38	0.02	77
Calcyclin/S100A6	gi\|13506725	10028.3	5.3	2.71*	0.03	0.03	0.08	0.09*	0.01	121
Carboxylesterase 3	gi\|31542380	62107.7	6.1	2.24*	0.05	0.2	0.3	0.45*	0.03	205
Phosphatidyl Inositol transfer protein (PITPN)	gi\|6679337	31873	5.97	2.03*	0.02	0.44	0.01	0.90	0.02	93
Heat shock protein 70_90 chaperone	gi\|20302113	62530.4	6.4	2.00*	0.02	0.23	0.02	0.46*	0.02	271
Proteosome Subunit macropain alpha (PSMA-1)	gi\|38328483	29498.8	6.15	1.99*	0.2	0.51	0.01	0.99	0.02	223

* significant change compared with untreated controls (p < 0.05; or greater than 1.7 fold increase)
Protein score – A "score" based on the frequency of a fragment molecular weight found in a protein of a given range of molecular weight. For every database entry scanned, all matching fragments contribute to the final score.
Protein C.I.% – Confidence interval that the program assigns to the peptide matches to protein. >95% score was considered statistically significant.

ISSN: 1465-993X