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Table 2 Typical Subject Demographics According to ATS/ERS 2004 Exacerbation Severity Level

From: Markers of exacerbation severity in chronic obstructive pulmonary disease

Variable/Exacerbation Severity Level Total Studies* Total Subjects# Point Estimate (95% CI) Study Data Distributions (± 2SD) Significance Test
      Z Test P Value
Age (years) 182 27,930    Levels  
Level I 71 16,917 66.0 (64.6 – 67.4) 51.2 – 80.8 I vs. II 0.067 (NS)
Level II 70 7,300 64.2 (62.9 – 65.5) 52.1 – 76.3 II vs. III 0.002
Level III 43 3,713 68.0 (65.9 – 70.1) 53.0 – 83.0 I vs. III 0.12 (NS)
Height (cm) 27 3,154    Levels  
Level I 14 2,581 169.7 (166.4 – 173.0) 155.1 – 184.3 I vs. II 0.25 (NS)
Level II 9 247 167.1 (164.0 – 170.2) 157.5 – 176.6 II vs. III 0.54 (NS)
Level III 4 326 169.1 (163.4 – 174.7) 157.3 – 180.9 I vs. III 0.85 (NS)
Weight (kg) 37 4,168    Levels  
Level I 15 3,176 72.8 (67.5 – 78.1) 46.9 – 98.7 I vs. II 0.36 (NS)
Level II 12 290 69.3 (63.8 – 74.7) 49.4 – 89.1 II vs. III 0.26 (NS)
Level III 10 702 63.6 (55.3 – 71.9) 35.5 – 91.7 I vs. III 0.067 (NS)
Body-Mass Index (kg/m 2 ) 29 4,250    Levels  
Level I 6 2,273 26.2 (23.8 – 28.7) 18.5 – 34.0 I vs. II 0.037 (NS)
Level II 19 1,729 23.4 (22.4 – 24.4) 19.5 – 27.3 II vs. III 0.84 (NS)
Level III 7 248 23.6 (21.2 – 26.0) 17.1 – 30.1 I vs. III 0.14 (NS)
Disease Years 21 8,606    Levels  
Level I 15 8,354 10.9 (7.8 – 14.1) 0 – 26.4 I vs. II 0.65 (NS)
Level II 5 228 12.9 (5.0 – 20.8) 0 – 30.2 II vs. III 0.67 (NS)
Level III 2 24 16.2 (3.9 – 28.4) 0 – 33.5 I vs. III 0.42 (NS)
  1. Symbols and Abbreviations: *Bold numbers indicate total studies (without duplicates) for the specific variable of interest; # Bold numbers indicate total subjects for all COPD exacerbation severity levels with respect to the specific variable of interest; Exacerbation severity levels are based on the following ATS/ERS 2004 operational classification scheme: Level I – treated at home; Level II – requires hospitalisation ; and Level III – leads to respiratory failure; ‡ Exacerbation Levels II and III were each compared to Level I using a two-tailed Z-test in which the alpha level was adjusted according to the Bonferroni Correction procedure to account for multiple testing; and NS = Non-significant difference.