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Table 1 Cytokine directed therapies for asthma

From: Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness

Treatment Effects Ref.
  Suppress AHR Reduce eosinophilia Other effects  
IFN-γ Yes Yes a. IFN-γ producing T cells increased;
b. Reduced IL-4 & IL-5 secretion
IL-10 Yes Yes a. Down-regulating synthesis of both Th1- & Th2- cytokines
b. Reduced both eosinophilia & neutrophilia
IL-12 Yes Yes a. Th1 skewed response;
b. specific IgE/IgG reduced;
5, 9, 11
IL-18 Yes Yes Combined IL-12 and IL-18 induce IFN-γ release 6
TGF-β Yes Yes Immuno- regulation, wound healing, and to shorten the inflammatory response 13, 21