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Figure 3 | Respiratory Research

Figure 3

From: Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Figure 3

Changes in luminal area of peripheral bronchi in response to muscarine (Mus, 10-6 M), 5-HT (10-6 M), and U44619 (10-5 M) in wild-type (M2/3R+/+) and M2/3R-/- mice. (A) 5-HT induces similar responses in both strains. The numbers in parentheses refer to the numbers of bronchi/number of lungs from which they were taken. Panel (B) expresses the 5-HT-induced constriction in percent of that evoked by U44619 in the first min after agonist application. The box plots shows percentiles 0, 25, 50 (median), 75, and 100; * indicates an individual data point beyond 3× S.D. (C) Original images of a peripheral bronchus of a wild-type and an M2/3R-/- double-knockout animal before and after agonist application. As depicted in (A), there is no constriction in response to muscarine in M2/3R-/- mice. On the other hand, both strains show identical responses to 5-HT and U44619.

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Respiratory Research

ISSN: 1465-993X

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