Figure 3
From: Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice
Effects of IL-13 on bronchial reactivity. To test if exogenous IL-13 induces BHR, lung slices from Balb/C wild-type mice were exposed to IL-13 and the response to 10-6 M ACH was quantified. Following incubation with IL-13 for 24 h, Ach-induced contraction and contraction velocity increased concentration dependently (n = 15 to 31 slices from 5 to 6 different mice for each data point, P < 0.05).