Table 3 Frequencies and patient characteristics of the subgroups formed by the combined limited allelic hap1otypes. Baseline FEV1 and PD20 were measured after a two week washout period followed by a two week placebo treatment period, before administration of the first dose of fenoterol.
From: Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics
Genotype | Frequency | Baseline FEV1 (% of predicted), mean (range) | Baseline PD20 geometric, mean (range) | Inhalation steroid dose, mean (range) |
|---|---|---|---|---|
I/III | 14 (31%) | 85 (59 – 107) | 141 (24 – 761) | 470 (200 – 1200) |
III/III | 10 (22%) | 86 (54 – 104) | 313 (92 – 1240) | 440 (200 – 1000) |
II/III | 5 (11%) | 81 (72 – 99) | 110 (20 – 371) | 380 (200 – 500) |
I/I | 10 (22%) | 85 (60 – 101) | 176 (29 – 672) | 530 (200 – 1000) |
I/II | 4 (9%) | 82 (70 – 94) | 74 (30 – 157) | 500 (400 – 800) |
II/II | 2 (4%) | 88 (82 – 93) | 148 (33 – 668) | 500 (200 – 800) |