Time period | Salmeterol | Placebo | Pooled estimate of difference | ||||
---|---|---|---|---|---|---|---|
 | No. of subjects | % with meaningful change | No. of subjects | % with meaningful change | Difference in % meaningful change | 95% CI | P value |
Intent to treat population | |||||||
Weeks 8–28 | 1150 | 45.3% | 1129 | 37.9% | 7.7% | 4.6, 10.7 | <0.0001 |
Weeks 8–52 | 1156 | 45.9% | 1131 | 37.9% | 7.9% | 5.1, 10.7 | <0.0001 |
Poorly reversible population | |||||||
Weeks 8–28 | 934 | 44.6% | 935 | 38.9% | 5.4% | 2.1, 8.8 | 0.0016 |
Weeks 8–52 | 939 | 45.3% | 937 | 39.0% | 5.9% | 2.8, 8.9 | 0.0002 |