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Table 1 Blood patterns

From: Hypoxia and dehydroepiandrosterone in old age: a mouse survival study

 

Treatment

before treatments

t = 5 weeks

t = 5 months

 

Blood hemoglobin content (g/dl)

Normoxia

Water

10.6 ± 0.5 (6)

12.4 ± 0.3 (7)

11.3 ± 0.9 (7)

**

 

Normoxia

DHEAS

11.3 ± 0.3 (9)

11.5 ± 0.4 (7)

12.0 ± 0.2 (5)

 
 

Hypoxia

Water

11.0 ± 0.4 (6)

14.3 ± 0.3 (6)

13.9 ± 0.6 (8)

 
 

Hypoxia

DHEAS

11.3 ± 0.7 (6)

14.3 ± 0.9 (6)

14.3 ± 1.2 (8)

 

Hematocrit (%)

Normoxia

Water

7.86 ± 0.3 (6)

8.65 ± 0.3 (7)

7.97 ± 0.7 (7)

**

 

Normoxia

DHEAS

8.03 ± 0.4 (9)

7.83 ± 0.3 (7)

8.61 ± 0.2 (5)

 
 

Hypoxia

Water

7.81 ± 0.3 (6)

9.70 ± 0.3 (6)

9.29 ± 0.5 (8)

 
 

Hypoxia

DHEAS

7.74 ± 0.6 (6)

9.68 ± 0.5 (6)

9.21 ± 0.7 (8)

 

Red cell count (103/mm3)

Normoxia

Water

42.2 ± 0.3 (6)

43.1 ± 0.5 (7)

42.9 ± 0.6 (7)

**

 

Normoxia

DHEAS

43.1 ± 0.5 (9)

43.2 ± 0.7 (7)

43.0 ± 0.6 (5)

 
 

Hypoxia

Water

43.3 ± 0.4 (6)

46.0 ± 0.8 (6)

47.5 ± 0.4 (8)

 
 

Hypoxia

DHEAS

42.9 ± 0.4 (6)

46.2 ± 1.8 (6)

47.8 ± 1.2 (9)

 

Mean red blood cell volume (μm3)

Normoxia

Water

42.2 ± 0.3 (6)

43.1 ± 0.5 (7)

42.9 ± 0.6 (7)

*

 

Normoxia

DHEAS

43.1 ± 0.5 (9)

43.2 ± 0.7 (7)

43.0 ± 0.6 (5)

 
 

Hypoxia

Water

43.3 ± 0.4 (6)

46.0 ± 0.8 (6)

47.5 ± 0.4 (8)

 
 

Hypoxia

DHEAS

42.9 ± 0.4 (6)

46.2 ± 1.8 (6)

47.8 ± 1.2 (9)

 

Mean cell hemoglobin concentration (g/dl)

Normoxia

Water

32.1 ± 0.2 (6)

33.1 ± 0.2 (7)

32.8 ± 0.3 (7)

 
 

Normoxia

DHEAS

32.6 ± 1.4 (9)

34.1 ± 0.3 (7)

32.6 ± 0.3 (5)

 
 

Hypoxia

Water

32.8 ± 0.4 (6)

32.0 ± 0.5 (6)

31.5 ± 0.3 (8)

 
 

Hypoxia

DHEAS

34.6 ± 0.3 (6)

32.4 ± 0.2 (6)

32.4 ± 0.3 (8)

 

Mean cell hemoglobin (pg)

Normoxia

Water

13.5 ± 0.1 (6)

14.3 ± 0.2 (7)

14.1 ± 0.3 (7)

 
 

Normoxia

DHEAS

14.1 ± 0.7 (9)

14.7 ± 0.1 (7)

14.0 ± 0.2 (5)

 
 

Hypoxia

Water

14.2 ± 0.2 (6)

14.7 ± 0.1 (7)

15 ± 0.1 (8)

 
 

Hypoxia

DHEAS

14.9 ± 0.2 (6)

14.9 ± 0.5 (6)

15.4 ± 0.3 (8)

 
  1. Red blood parameters for the different treatments at different times. Blood hemoglobin content, hematocrit and red cell count were elevated under hypoxia compared to normoxia, at t = 5 weeks (p < 0.01) and similarly at t = 5 months (p < 0.01) (**). Mean red blood cell volume was slightly elevated under hypoxia compared to normoxia, at t = 5 weeks (p < 0.05) and slightly more at t = 5 months (p < 0.05) (*). Mice treated with dehydroepiandrosterone (named DHEAS in the table) had the same blood patterns than matching mice that did not received dehydroepiandrosterone (named Water in the table), whether under normoxia or hypoxia.
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Respiratory Research

ISSN: 1465-993X

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