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Table 4 Associations between reflux symptoms and respiratory outcomes in atopic and non-atopic Study members.

From: Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort

  Heartburn Regurgitation Heartburn and Regurgitation
  Non-atopic Atopic   Non-atopic Atopic   Non-atopic Atopic  
  OR (95% CI) OR (95% CI) p-itn OR (95% CI) OR (95% CI) p-itn OR (95% CI) OR (95% CI) p-itn
Asthma 1.81 (0.64, 5.17) 1.96 (1.12, 3.44) 0.873 4.03 (1.11, 14.5) 2.54 (1.23, 5.24) 0.603 3.51 (0.80, 15.3) 3.16 (1.35, 7.38) 0.827
Wheeze 2.88 (1.40, 5.90) 1.30 (0.76, 2.20) 0.072 7.27 (2.23, 23.7) 1.93 (0.95, 3.93) 0.062 6.56 (1.68, 25.6) 2.54 (1.07, 6.00) 0.253
Cough 4.67 (1.98, 11.0) 1.46 (0.73, 2.92) 0.039 5.90 (1.94, 18.0) 2.88 (1.30, 6.38) 0.315 10.8 (3.02, 38.6) 2.87 (1.12, 7.34) 0.099
BDR 2.81 (0.70, 11.3) 2.08 (0.99, 4.36) 0.760 7.57 (1.76, 32.5) 1.76 (0.64, 4.86) 0.108 12.7 (2.71, 59.6) 2.08 (0.67, 6.50) 0.067
  Coeff (95% CI) Coeff (95% CI)   Coeff (95% CI) Coeff (95% CI)   Coeff (95% CI) Coeff (95% CI)  
FEV1/FVC 0.80 (-1.24, 2.84) -1.15 (-3.13, -0.82) 0.213 -2.43 (-5.37, 0.51) -2.27 (-4.95, 0.41) 0.940 -1.91 (-5.34, -1.51) -2.56 (-5.79, 0.66) 0.808
  1. Non-atopic groups (n = 278) and atopic (n = 536) defined by skin-prick tests at age 21. The FEV1/FVC ratio is analysed by linear regression. All other analyses use logistic regression. Analyses use the respiratory outcomes as the dependent variables and are adjusted for BMI and sex. OR = odds ratio, Coeff = coefficient, 95% CI = 95% confidence intervals, p-itn = p value for interaction between atopic status and reflux symptoms, BDR = 10% or greater increase in FEV1 following salbutamol.