Figure 2

Airway hyperreactivity in RSV and/or Ova exposed mice. Mice were infected with RSV as neonates (RSS) and exposed to Ova 5 wks later (ROO). Controls were sham infected and exposed to Saline (SAL) or Ova (OVA). A. Lung resistance of each group is plotted as a function of increasing doses of inhaled MeCh, using single compartment model. B. Penh is plotted as a function of increasing dose of inhaled MeCh (0 to 50 mg/ml). Data were collected on protocol days 69 (A) or 96 (B), normalized to saline airway responses as described in methods, and expressed as mean ± SEM. n = 4–5/group. ***p < 0.001; **p < 0.01.