Table 1 Summary of upregulated genes in IPAH showing gene abbreviation, accession number, location of SSH cDNA clone sequence on gene transcript, encoded protein name and chromosomal localisation.
From: Upregulated Genes In Sporadic, Idiopathic Pulmonary Arterial Hypertension
Gene | Accession | Clone | Protein | Chromosome |
|---|---|---|---|---|
Extracellular Proteins | Â | Â | Â | Â |
AMOTL2 | NM_016201 | 3'UTR | Angiomotin like-2 | 3q21-q22 |
SPARCL1 | NM_004684 | Coding & 3'UTR | Hevin | 4q22.1 |
DCN | NM_001920 | 5'UTR & coding | Decorin isoform A | 12q21 |
TIMP3 | NM_000362 | 3'UTR | Tissue inhibitor of metalloproteinase-3 | 22q12.3 |
FLJ23191 | AAQ89180 | 3'UTR | VLLH2748 | 4q27 |
Membrane Proteins | Â | Â | Â | Â |
ROBO4 | NM_019055 | Coding & 3'UTR | Magic roundabout | 11q24.2 |
THBD | NM_000361 | 3'UTR | Thrombomodulin | 20p12-cen |
CD9 | NM_001769 | Coding & 3'UTR | Cluster of differentiation-9 | 12p13.3 |
TM4SF1 | NM_014220 | Coding & 3'UTR | L6 antigen | 3q21-q25 |
GPR107 | AF376725 | 3'UTR | G protein-coupled receptor 107 | 9q34.11 |
Nuclear | Â | Â | Â | Â |
EGLN1 | NM_022051 and AF334711 | 3'UTR | Hypoxia-inducible factor prolyl hydroxylase 2 | 1q42.1 |
TACC1 | NM_006283 | 3'UTR | Transforming acidic coiled coil-1 | 8p11 |
MBNL1 | NM_021038 | 3'UTR | Muscleblind-1 | 3q25 |
CCNI | NM_006835 | Coding | Cyclin I | 4q21.1 |
CCNL1 | AF180920 | Coding | Cyclin L1 | 3q25.31 |
NPIP | NM_006985 | Coding | Nuclear pore complex interacting protein | 16p13-p11 |
Cytoplasmic | Â | Â | Â | Â |
YWHAZ | NM_003406 | 3'UTR | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 8q23.1 |
DAB2 | NM_001343 | 3'UTR | Disabled homolog 2 | 5p13 |
COPA | NM_004371 | Coding & 3'UTR | α-coatomer protein | 1q23-q25 |
VPS35 | AF191298 | Coding | Vesicle protein sorting 35 | 16q12 |
C14orf153 | NM_032374 | Coding | Chromosome 14 open reading frame 153 | 14q32.32-q32.33 |
Enzymes | Â | Â | Â | Â |
FMO2 | NM_001460 and 3'UTR AK098145 | 3'UTR | Pulmonary flavin-containing monooxygenase 2/Dimethylaniline monooxygenase | 1q23-q25 |
SNRK | NM_017719 | 3'UTR | Sucrose non-fermenting protein-related kinase-1 | 3p22.1 |
ASAH1 | NM_177924 and NM_004315 | Coding & 3'UTR | N-acylsphingosine amidohydrolase/acid ceramidase | 8p22-p21.3 |
PDK4 | NM_002612 and AF334710 | 3'UTR | Pyruvate dehydrogenase kinase-4 | 7q21.3-q22.1 |
ALDH1A1 | NM_000689 | Coding | Aldehyde dehydrogenase 1A1 | 9q21.13 |
MAOA | NM_000240 | Coding & 3'UTR | Monoamine oxidase A | Xp11.23 |