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Table 4 Characteristics of patients with alveolitis

From: Functional, radiological and biological markers of alveolitis and infections of the lower respiratory tract in patients with systemic sclerosis

  BAL: alveolitis
16 patients
BAL: inactive
26 patients
P
Age (years) mean ± sd 57.0 ± 9.8 57.1 ± 11.8 ns
Disease duration (years) median (I.Q. range) 7.5 (3–16) 5 (1.5–12) ns
Sex n (%) 1 (6.25%) 2 (7.7%) ns
Autoantibodies pattern:    
ACA n (%) 2 (12.5%) 8 (30.8%) ns
AntiScl 70 n (%) 12 (75.0%) 11 (42.3%) ns
Antinucleolus n (%) 0 (0.0%) 4 (15.4%) ns
AntiRNP n (%) 1 (6.25%) 1 (3.8%) ns
ACA/Scl 70/nucleolus/RNP negative n (%) 1 (6.25%) 2 (7.7%) ns
Skin involvement:    
dSSc n (%) 12 (75.0%) 5 (19.2%) 0.0009
lSSc n (%) 4 (25.0%) 21 (80.8%) 0.0009
Modified Rodnan Skin Score mean ± sd 16.3 ± 9.4 10.1 ± 9.1 0.038
Modified Rodnan Skin score >14 n (%) 8 (50.0%) 5 (19.2%) 0.036
PFTs: FVC mean (%) ± sd 76.1 ± 27.6 101.9 ± 17.0 0.0005
DLCO mean (%) ± sd 43.9 ± 16.6 54.8 ± 11.0 0.0086
FVC and DLCO ≤ 79% n (%) 12 (75.0%) 2 (7.7%) < 0.0001
FVC and DLCO ≤ 49% n (%) 10 (62.5%) 2 (7.7%) < 0.0001
FVC ≥ 80% and DLCO ≤ 79% n (%) 3 (18.8%) 24 (92.3%) < 0.0001
FVC ≥ 80% and DLCO ≤ 49% n (%) 10 (62.5%) 9 (34.6%) ns
FVC and DLCO ≥ 80% n (%) 1 (6.3%) 0 (0.0%) -
PASP ≥ 40 mmHg n (%) 6 (37.5%) 1 (3.8%) 0.008
≥ 60 mm Hg n (%) 1 (6.3%) 0 (0.0%) -
HRCT: interstitial score mean ± sd 6.9 ± 3.5 7.3 ± 1.9 ns
alveolar score mean ± sd 9.1 ± 5.3 5.0 ± 3.1 0.0095
C reactive protein mean (mg/l) ± sd 8.6 ± 10.8 6.6 ± 6.7 ns
IL-6 plasma levels (pg/ml) mean ± sd 6.0 ± 10.8 2.4 ± 4.1 0.041
BAL with positive microbiological culture n (%) 5 (31.3%) 5 (19.2%) ns
Smokers n (%) 1 (6.3%) 4 (15.4%) ns
Ex-smokers n (%) 3 (18.8%) 5 (19.2%) ns
  1. BAL: bronchoalveolar lavage; ACA: anticentromere antibodies; antiScl 70: antitopoisomerasi I antibodies; antiRNP: antiribonucleoproteins antibodies; dSSc: diffuse skin involvement; lSSc: limited skin involvement; FVC: forced vital capacity; DLCO: diffusing capacity for carbon monoxide; PASP: pulmonary artery systolic pressure; HRCT: high resolution computed tomography.