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Table 1 Phenotypic frequencies of the polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects.

From: Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69

 

Be-exposed controls (n = 45)

Be-Hypersensitive (n = 22)

  

HLA-DRB1 polymorphisms 1

N positive subjects (%)

N positive subjects (%)

OR 2

p 3

Ser13

28 (62.2%)

20 (90.9)

6.07

0.015

Tyr26

7 (15.6%)

10 (45.5%)

4.52

0.009

His32

21 (46.7%)

17 (77.3%)

3.89

0.017

Asn37

17 (37.8%)

16 (72.7%)

4.39

0.007

Phe47

30 (66.7%)

21 (95.5%)

10.50

0.011

Arg74

7 (15.6%)

10 (45.5%)

4.52

0.009

HLA-DQB1 polymorphism 4

    

Leu26

32 (71.1%)

21 (95.5%)

8.53

0.021

HLA-DRB3 polymorphisms 5

N = 30

N = 17

  

Arg11

8 (26.7%)

12 (70.6%)

6.60

0.008

Tyr26

8 (26.7%)

12 (70.6%)

6.60

0.008

Asp28

8 (26.7%)

12 (70.6%)

6.60

0.008

Leu38

8 (26.7%)

12 (70.6%)

6.60

0.008

Ser60

8 (26.7%)

12 (70.6%)

6.60

0.008

Arg74

8 (26.7%)

12 (70.6%)

6.60

0.008

  1. 1. HLA-DRB1 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DRB1 polymorphic variants analyzed at positions: 9, 10, 11, 12, 13, 16, 26, 28, 30, 32, 37, 38, 47, 57, 58, 60, 67, 70, 71, 73, 74, 77, 85, 86.
  2. 2. Odds ratio with respect to Be-exposed controls.
  3. 3. p value (χ2 analysis) with respect to Be-exposed controls.
  4. 4. HLA-DQB1 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DQB1 polymorphic variants analyzed at positions: 9, 13, 14, 23, 26, 28, 30, 37, 38, 45, 46, 47, 52, 53, 55, 56, 57, 66, 67, 70, 71, 74, 75, 77, 84, 85, 86, 87, 89, 90.
  5. 5. HLA-DRB3 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DRB3 polymorphic variants analyzed at positions: 8, 11, 26, 28, 30, 37, 38, 39, 51, 57, 58, 60, 67, 74, 77, 86. No polymorphisms were found associated to BH in HLA-DPGlu69 negatives in the HLA-DRB4 and DRB5 loci and HLA-DP locus.
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Respiratory Research

ISSN: 1465-993X

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