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Table 1 Phenotypic frequencies of the polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects.

From: Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69

  Be-exposed controls (n = 45) Be-Hypersensitive (n = 22)   
HLA-DRB1 polymorphisms 1 N positive subjects (%) N positive subjects (%) OR 2 p 3
Ser13 28 (62.2%) 20 (90.9) 6.07 0.015
Tyr26 7 (15.6%) 10 (45.5%) 4.52 0.009
His32 21 (46.7%) 17 (77.3%) 3.89 0.017
Asn37 17 (37.8%) 16 (72.7%) 4.39 0.007
Phe47 30 (66.7%) 21 (95.5%) 10.50 0.011
Arg74 7 (15.6%) 10 (45.5%) 4.52 0.009
HLA-DQB1 polymorphism 4     
Leu26 32 (71.1%) 21 (95.5%) 8.53 0.021
HLA-DRB3 polymorphisms 5 N = 30 N = 17   
Arg11 8 (26.7%) 12 (70.6%) 6.60 0.008
Tyr26 8 (26.7%) 12 (70.6%) 6.60 0.008
Asp28 8 (26.7%) 12 (70.6%) 6.60 0.008
Leu38 8 (26.7%) 12 (70.6%) 6.60 0.008
Ser60 8 (26.7%) 12 (70.6%) 6.60 0.008
Arg74 8 (26.7%) 12 (70.6%) 6.60 0.008
  1. 1. HLA-DRB1 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DRB1 polymorphic variants analyzed at positions: 9, 10, 11, 12, 13, 16, 26, 28, 30, 32, 37, 38, 47, 57, 58, 60, 67, 70, 71, 73, 74, 77, 85, 86.
  2. 2. Odds ratio with respect to Be-exposed controls.
  3. 3. p value (χ2 analysis) with respect to Be-exposed controls.
  4. 4. HLA-DQB1 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DQB1 polymorphic variants analyzed at positions: 9, 13, 14, 23, 26, 28, 30, 37, 38, 45, 46, 47, 52, 53, 55, 56, 57, 66, 67, 70, 71, 74, 75, 77, 84, 85, 86, 87, 89, 90.
  5. 5. HLA-DRB3 polymorphisms found associated with Be-hypersensitivity in HLA-DPGlu69 negative subjects among the overall HLA-DRB3 polymorphic variants analyzed at positions: 8, 11, 26, 28, 30, 37, 38, 39, 51, 57, 58, 60, 67, 74, 77, 86. No polymorphisms were found associated to BH in HLA-DPGlu69 negatives in the HLA-DRB4 and DRB5 loci and HLA-DP locus.