Figure 4

Dose-dependent reduction of cell infiltration in wild-type mice exposed to LPS upon PPARα activation by fenofibrate. Number of total cells, neutrophils and macrophages in BALF from C57BL/6 mice exposed to LPS and treated with increasing doses of fenofibrate (0.15 to 15 mg/day) or its vehicle (1% CMC), when compared to mice exposed to saline and treated with CMC. Data are mean ± SEM of n = 6 animals. Statistically significant differences at α = 0.05: (*) when compared to mice exposed to saline and treated with CMC; (#) when compared to mice exposed to LPS and treated with CMC.