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Figure 5 | Respiratory Research

Figure 5

From: Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation

Figure 5

These micrographs illustrate characteristic eosinophil phenotypes present in mouse airways in this study: (A) viable non-degranulating eosinophil, the only phenotype found in lung tissues of allergen challenged animals; (B) apoptotic eosinophil exhibiting nuclear condensation, cell shrinkage, and an intact cell membrane; (C) an apoptotic eosinophil exhibiting secondary necrosis involving cell membrane rupture and piecemeal degranulation; (D) a cytolytic eosinophil exhibiting chromatolysis, cell membrane rupture, and spilling of electron-dense specific granules into the tissue (arrow).

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