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Table 5 Pro-SP-B and pro-SP-C in 7 children with chronic respiratory distress of unknown cause (cRD)

From: Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease

 

pro-SP-B

pro-SP-C

Detecting antibody

CTERMB

CFLANK

NFLANK

NFPROX

NPROSP-C-C2

Mr of bands (kDa)

     

40–42

57%* [2,5–7]

14% [7]

-

-

-

25–26

71% [2,3,5–7]

38%+ [4,6,7]

57% [2,4,5,6]

-

-

19–21

-

-

14% [6]

14%§ [6]

-

15

-

-

-

29%§ [2,7]

-

9

14% [6]

14% [7]

-

-

14% [6]

3.6

-

-

-

14%§ [3]

-

  1. Percent of subjects with bands and identification numbers of those subjects in whom bands reacting with the anti-pro-SP-B-antibodies CTERMB, NFLANK, CFLANK, NFPROX and displaced by the CTERMB, NFLANK, CFLANK, NFPROX peptides, or the anti-pro-SP-C-antibody NPRO-SP-C-C2 and displaced by the respective peptide, were identified. Differences in the frequency of bands of all the disease groups were evaluated by the Fisher exact test and those with a P < 0.05 were indicated by an * for comparison with the healthy control group or by a + for comparison with the disease control group, bronchitis (see table 2). §indicates a significant difference to the disease control group, bronchitis, when all NFPROX reactive bands were combined (P < 0.01). The identification numbers of the patients are given in square brackets []. Numbers in bold indicate bands not identified by the CTERMB antibodies.