Table 1 Patient characteristics, lavage protein content and apparent molecular weight of SP-B and SP-C
From: Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease
Children | N (males) | Age (y) | Time of follow up (years), outcome | Protein (μg/ml) | SP-B Mr of band (kDa) | SP-C Mr of band (kDa) |
|---|---|---|---|---|---|---|
without lung disease | 15 (8) | 5.4 (0.5–12) | not applicable | 62 (21–275) | 7.1 (5.9–11.6) | 4.8 (4.3–5.8) |
with chronic obstructive bronchitis | 19 (13) | 5.3 (1–15) | 4 (0.3–10) years, 14/19 better, 3/19 same, 1/19 worse, 1/19 unknown | 76 (17–207) | 11.0 (8–13.5) | 5.2 (3.9–5.6) |
with no SP-B | 6 (3) | neonates | 5 pts [2–6] died at 0.3 (0.1–0.4) years, pt [1] alive with corticosteroids | 318* (131–2048) | no SP-B bands in any pt | 5.6 (3.6–6.5) pt [4] no SP-C |
with pulmonary alveolar proteinosis | 15 (9) | 1.4 (0.6–4) | Pts [6,10,14,15] died at ages 1.3 and 1.7 years and at 4 and 5 months of age. 11/15 alive with repetitive whole lung lavages and oxygen-dependence | 495** (87–2099) | 10.5 (8.8–12.5) | 4.8 (3.6–5.4) |
with chronic respiratory distress of unknown cause | 7 (7) | neonates, one subject 4 months | 4 died at age 8 days to 4 months, 3 [3,6,7] lost on follow up | 449* (184–474) | 9.7 (6.3–11.2) | 5.6 (4.3–7) |