Table 7 Studies measuring serum biomarkers in patients with sarcoidosis
Investigator | Patients Controls | Biomarker / Summary | ROC curve analysis Cut-off values | Specificity / Sensitivity Diagnostic accuracy | Limitations |
|---|---|---|---|---|---|
Ziegenhagen et al.104 | 77 50 | TNF-a release from alveolar macrophages and serum level of sIL-2R are prognostic markers for sarcoidosis patients | No | Not estimated | No serial measurements / No ROC curve analysis / cut-off values |
Ziegenhagen et al. 105 | 73 48 | BAL and serological parameters reflect the severity of sarcoidosis | No | Not estimated High predictive value for neopterin+ sIL-2R | No serial measurements / No ROC curve analysis / cut-off values |
Grutters et al. 106 | 47 | Positive correlation between sIL-2R serum levels and the disease activity and severity in patients with sarcoidosis | No | Not estimated | Small number of patients with serial measurement / No ROC curve analysis / cut-off values |
Rothkrantz-Kos et al.109 | 144 282 | Potential usefulness of inflammatory markers to monitor respiratory functional impairment in sarcoidosis | Yes sIL-2R: 750 U/ ml sIL-2R: 1300 U/ml | sIL-2R: 94 - 82% sIL-2R: 82 - 94% | Discrepancies between treated and untreated patients / No serial measurements / Retrospective study / No correlation with radiological findings |
Hashimoto et al. 117 | 26 | Correlation of plasma MCP-1 and MIP-1a levels with disease activity and clinical course of sarcoidosis patients | No | Not estimated | Small number of patients / No ROC curve analysis / cut-off values / No determination of the cytokines' cellular sources |
Iyonaga et al. 118 | 47 10 | MIP-1 serum levels estimate the activity of granuloma formation in sarcoidosis | No | Not estimated | Small number of patients / No ROC curve analysis / cut-off values / No correlation with radiological findings |
Kobayashi et al. 119 | 47 | Serum KL-6 for the evaluation of active pneumonitis in pulmonary sarcoidosis | No | Not estimated | Small number of patients / No follow-up laboratory data |
Hermans et al. 120 | 117 117 | Serum CC16 levels, a marker of the integrity of the air-blood barrier in sarcoidosis | No | Not estimated | Non ILD- specific marker / Potential influence by tobacco smoking / Poor discriminative value |
Janssen et al. 122 | 79 38 | Elevated serum CC16, KL-6, and SP-D levels reflect pulmonary disease severity and prognosis in sarcoidosis patients | Yes CC16: 12.7 ng/ml KL-6: 223 U/ml SP-D: 91.7 ng/ml | CC16: 84 - 73- 73% KL-6: 84 - 86 - 86% SP-D: 84 - 66 - 66% | Non ILD- specific markers / Retrospective study / No serial measurement |