Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors

Schermuly, Ralph Theo; Inholte, Christiane; Ghofrani, Ardeschir Hossein; Gall, Henning; Weissmann, Norbert; Weidenbach, Andreas; Seeger, Werner; Grimminger, Friedrich

doi:10.1186/1465-9921-6-76

Table 1 Summarized data of hemodynamics and blood gases in rabbits with U46619-induced pulmonary hypertension and inhalation of iloprost in the absence and presence of sub-threshold intravenous PDE inhibitors.^Δ

From: Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors

	Control/U46619		U46619/Ilo		U46619/Ilo/Sil		U46619/Ilo/8MM-IBMX		U46619/Ilo/Mota		U46619/Ilo/8MM-IBMX/Sil		U46619/Ilo/Mota/Sil
	Pre	post	pre	post	pre	post	pre	post	pre	post	pre	post	pre	post
P _SA , mmHg	111 ± 4	105 ± 3	111 ± 3	111 ± 3	106 ± 3	105 ± 2	107 ± 2	104 ± 4	100 ± 3	96 ± 3	99 ± 3	97 ± 2	93 ± 4	92 ± 4
P _PA , mmHg	15.9 ± 0.3	25.9* ± 0.4	25.8 ± 0.6	22.7* ± 0.4	25.7 ± 0.2	21.8* ± 0.3	24.8 ± 0.7	21.1* ± 0.8	27.3 ± 1,1	21.0* ± 0.6	25.0 ± 0.4	20.4* ± 0.3	24.7 ± 0.4	19.3* ± 0.4
CO, ml/min	555 ± 23	544 ± 38	432 ± 27	452 ± 25	444 ± 19	488 ± 35	393 ± 24	437 ± 29	417 ± 21	446 ± 15	454 ± 27	505 ± 30	501 ± 35	555 ± 52
PAOP, mmHg	7.2 ± 1.2	7.6 ± 0.8	8.0 ± 1.1	7.3 ± 1.3	7.7 ± 0.9	7.4 ± 1.1	7.7 ± 0.8	7.6 ± 1.2	6.9 ± 1.3	7.3 ± 1.1	7.7 ± 1.2	7.7 ± 1.1	7.8 ± 0.8	7.2 ± 1.1
PVRI, dyne/s cm ^-5 m ²	275 ± 34	592* ± 49	725 ± 39	599* ± 37	713 ± 58	519* ± 44	765 ± 67	543* ± 63	861 ± 64	540* ± 71	670 ± 75	442* ± 52	593 ± 56	383* ± 61
P _a O ₂ , mmHg	226 ± 17	199 ± 12	183 ± 12	177 ± 10	191 ± 6	203 ± 4	228 ± 7	188 ± 12	201 ± 7	197 ± 11	171 ± 10	173 ± 11	179 ± 10	174 ± 14
PH _a	7.42 ± 0.02	7.35 ± 0.02	7.37 ± 0.03	7.32 ± 0.01	7.36 ± 0.02	7.32 ± 0.02	7.41 ± 0.02	7.38 ± 0.02	7.33 ± 0.01	7.31 ± 0.01	7.35 ± 0.02	7.34 ± 0.02	7.33 ± 0.02	7.29 ± 0.01
P _a CO ₂ mmHg	42.7 ± 1.3	43.0 ± 3.5	41.5 ± 2.0	40.7 ± 1.0	42.0 ± 4.1	45.2 ± 4.0	36.2 ± 1.6	37.7 ± 1.5	44.3 ± 1.2	46.2 ± 1.2	45.9 ± 1.7	47.6 ± 1.4	36.9 ± 2.0	38.0 ± 1.8
P _v O ₂ , mmHg	46.7 ± 1.3	44.1 ± 2.4	39.9 ± 1.7	42.6 ± 1.2	39.7 ± 2.3	44.9 ± 1.4	35.8 ± 1.5	39.7 ± 2.1	40.7 ± 1.64	42.7 ± 1.2	39.7 ± 2.5	44.9 ± 2.6	41.8 ± 1.2	44.0 ± 1.6
PH _v	7.30 ± 0.01	7.24 ± 0.02	7.34 ± 0.03	7.29 ± 0.01	7.23 ± 0.02	7.20 ± 0.02	7.37 ± 0.02	7.31 ± 0.03	7.28 ± 0.01	7.26 ± 0.01	7.29 ± 0.02	7.28 ± 0.02	7.28 ± 0.02	7.24 ± 0.01
P _v CO ₂ , mmHg	49.8 ± 0.9	54.9 ± 1.2	48.9 ± 2.3	49.7 ± 1.1	59.2 ± 1.6	60.6 ± 1.4	44.6 ± 2.5	44.9 ± 2.5	52.4 ± 1.4	54.2 ± 1.4	53.8 ± 2.0	52.9 ± 2.2	42.5 ± 2.3	45.9 ± 1.6

^Δ P_SA, mean aortic pressure; P_PA, mean pulmonary artery pressure; CO, cardiac output; PAOP, pulmonary artery occlusion pressure; PVR, pulmonary vascular resistance; P_aO₂, arterial PO₂; pH_a, arterial pH; P_aCO₂, arterial PCO₂; P_vO₂, central venous PO₂; pH_v, central venous pH; P_vCO₂, central venous PCO₂; Ilo, iloprost; Sil, sildenafil; 8MM-IBMX, 8-Methoxymethyl-3-isobutyl-1-methylxanthine; Mota, motapizone. The first two columns give summarized data for all groups. All other columns give pre- and post-iloprost nebulization data in animals undergoing preceding sub-threshold PDE-inhibitor infusion (n = 8 for each group). Asterisks indicate significant differences between pre and post-aerosolization values (* = p < 0.05).

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