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Figure 3 | Respiratory Research

Figure 3

From: Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors

Figure 3

Influence of iloprost nebulization and its combination with sub-threshold doses of intravenous PDE inhibitors on U46619-elicted pulmonary hypertension. Decrease in pulmonary vascular resistance (PVR, in %) at the end of the nebulization period is given (mean ± SEM of 8 independent experiments each). The PDE inhibitors were pre-applied as short-term infusion as follows: 200 μg/kg × min 8-Methoxymethyl-IBMX, 1 μg/kg × min sildenafil, 5 μg/kg × min motapizone. *, p < 0.05 as compared to pre-nebulization value.

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