Table 2 Positional candidate genes from linkage analysis of pulmonary tolerance to BAL PMNs and macrophages following repeated ZnO exposure.
From: Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice
Chromosome | QTL Interval | Location | Human Orthology | Candidate Gene |
|---|---|---|---|---|
Chr 1 (PMNs) | 51–73 cM | 52.0 cM | 2 (q33-q37) | Ccl20, chemokine (C-C motif) ligand 20 |
| Â | Â | 67.4 cM | 2 (q21) | Cxcr4 chemokine (C-X-C motif) receptor 4 |
| Â | Â | 69.9 cM | 1 (q31-q32) | Il10, interleukin 10 |
Chr 5 (Macrophages) | 43–58 cM | 51.0 cM | 4 (q13-q21) | Areg, amphiregulin |
| Â | Â | 51.0 cM | 4 (q13-q21) | Btc, betacellulin |
| Â | Â | 51.0 cM | 4 (q21) | Cxcl1, chemokine (C-X-C motif) ligand 1 |
| Â | Â | 51.0 cM | 4 (q21) | Cxcl2, chemokine (C-X-C motif) ligand 2 |
| Â | Â | 53.0 cM | 4 (q21) | Cxcl5, chemokine (C-X-C motif) ligand 5 |
| Â | Â | 53.0 cM | 4 (q21) | Cxcl9, chemokine (C-X-C motif) ligand 9 |
| Â | Â | 53.0 cM | 4 (q21) | Cxcl10, chemokine (C-X-C motif) ligand 10 |
| Â | Â | 56.0 cM | 4 (q21-q25) | Spp1, secreted phosphoprotein 1 |