Table 2 Baseline characteristics and genotype frequencies for the 6 SNPs in both cohorts.
From: Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
| Â | Â | Adult Study N = 401 | Â | CAMP N = 652 | Â |
|---|---|---|---|---|---|
Age, mean(sd) | Â | 39.2 (13.7) | Â | 8.9 (2.1) | Â |
Gender, male, n(%) | Â | 171 (42.8) | Â | 393 (60.3) | Â |
FEV1 (%predicted), mean (sd) | Â | 71.7 (12.8) | Â | 94.3 (14.2) | Â |
Number of positive skin tests, median (minimum, maximum) | Â | --- | Â | 4 (0, 18) | Â |
Eosinophil count, geometric mean (sd) | Â | --- | Â | 5.86 (2.06) | Â |
IgE, geometric mean (sd) | Â | --- | Â | 404.0 (4.9) | Â |
Paternal asthma, n(%) | Â | --- | Â | 125 (19.2) | Â |
Maternal asthma, n(%) | Â | --- | Â | 164 (25.2) | Â |
Maternal cigarette smoking during pregnancy, n(%) | Â | --- | Â | 88 (13.5) | Â |
SNP genotypes, n(%) | Â | Â | HWE p-value | Â | HWE p-value |
G3363a16 | GG | 145 (36.2) | Â | 245 (37.6) | Â |
| Â | GT | 153 (38.0) | 0.6 | 291 (44.6) | 0.7 |
| Â | TT | 46 (11.5) | Â | 80 (12.3) | Â |
| Â | missing | 57 (14.2) | Â | 36 (5.5) | Â |
G3363a3 | GG | 342 (85.2) | Â | 582 (89.3) | Â |
| Â | GA | 1 (0.2) | 0.004 | 2 (0.3) | 1.0 |
| Â | AA | 1 (0.2) | Â | 0 | Â |
| Â | missing | 57 (14.2) | Â | 68 (10.4) | Â |
G3363a4 | GG | 137 (34.0) | Â | 218 (33.4) | Â |
| Â | GC | 175 (43.8) | 0.3 | 291 (44.6) | 0.5 |
| Â | CC | 70 (17.5) | Â | 85 (13.0) | Â |
| Â | missing | 19 (4.8) | Â | 58 (8.9) | Â |
rs1026916 | GG | 164 (41.0) | Â | 227 (34.8) | Â |
| Â | GA | 181 (45.0) | 0.8 | 233 (35.7) | 0.2 |
| Â | AA | 52 (13.0) | Â | 74 (11.3) | Â |
| Â | missing | 4 (1.0) | Â | 118 (18.1) | Â |
rs1905340 | CC | 203 (50.8) | Â | 254 (39.0) | Â |
| Â | CA | 159 (39.5) | 1.0 | 191 (29.3) | 0.6 |
| Â | AA | 30 (7.5) | Â | 41 (6.3) | Â |
| Â | missing | Â | Â | 166 (25.5) | Â |
rs957971 | CC | 156 (39.0) | Â | 242 (37.1) | Â |
| Â | CG | 172 (42.8) | 0.6 | 260 (39.9) | 1.0 |
| Â | GG | 54 (13.5) | Â | 70 (10.7) | Â |
| Â | missing | Â | Â | 80 (12.3) | Â |