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Table 2 Inflammation in bronchial biopsies from smokers with COPD and asymptomatic smokers

From: Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers

 

Total COPD

Symptomatic smokers

Asymptomatic smokers

 

GOLD I-III

GOLD 0

 

Biopsies, n

19

8

24

   CD3, %positive area

1.05 (0.2–9.24)

0.68 (0.19–1.7)

0.76 (0.17–2.4)

   CD4, %positive area

0.041 (0.01–0.57)

0.073 (0–0.18)

0.04 (0–0.15)

   CD8, %positive area

0.27 (0.03–2.55)

0.19 (0.02–1.53)

0.33 (0.3–1.25)

   CD4/CD8 ratio

0.19 (0.1–4.4)

0.39 (0.04–1.2)

0.18 (0–0.91)

   CD20, %positive area

0.003 (0–3.40)

0.003 (0–0.23)

0.005 (0–0.12)

   NP57, %positive area

0.025 (0–0.13)

0.05 (0–0.23)

0.021 (0–0.36)

   CD68, %positive area

0.035 (0–0.21)

0.056 (0–0.16)

0.041 (0–0.32)

   EG2, %positive area

0.021 (0–0.31)

0.049 (0–0.15)

0.063 (0–0.59)

   AA1, %positive area

0.15 (0.01–0.91)

0.22 (0–0.41)

0.22 (0.1–1.16)

  1. Values expressed in median (range). Abbreviations: CD20 = B-cell marker, NP57 = neutrophil elastase, CD68 = macrophages, EG2 = eosinophils, AA1 = mast cell tryptase.
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Respiratory Research

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