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Table 2 IC50 values for the inhibition of cytokine mRNA synthesis by combined administration of MAPK inhibitors in vitro. IC50values were calculated from data shown in Figure 8.

From: Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia

μM

IFNγ (U0126)

IFNγ (U0126+SB203580)

IL-13 (U0126)

IL-13 (U0126+SB203580)

α-CD3/B7-2

0.29

0.68

0.28

0.97

α-CD3/B7-H2

0.19

1.14

0.21

0.73

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Respiratory Research

ISSN: 1465-993X

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