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Table 1 Clinical subdivisions of chronic rhinosinusitis based on nasal polyposis and aspirin – sensitivity (mean with 95% CI, or % of group).

From: Pathophysiological classification of chronic rhinosinusitis

1st Decision

Chronic Rhinosinusitis (CRS; n = 99)

Nasal Polyps

Present: N = 50

Absent: N = 49

2nd Decision

Nasal Polyps with Aspirin Sensitivity (NPasa)

Nasal Polyps with Other Features (NPother)

CRS without (s) Nasal Polyps (CRSsNP)

Osteomeatal Complex Disease (OMC)

Aspirin Sensitivity

17/17 (100%) (airways)

0/33 (0%) [<10-9] (airways)

1/28 (4%) [<10-9] (urticaria)

1/21 (5%) [<10-9] (urticaria)

May CT Scan Grade A

3.35 (3.02 to 3.69)

3.10 (2.85 to 3.34) ¶¶

2.43 (2.22 to 2.64) §§§ † ¶

1 (1 to 1) §§§

Blood Eos > 4% B

11/17 (65%)

13/33 (39%)

9/27 (33%) [0.03]

4/20 (20%) [0.006]

% Males

4/17 (24%)

12/33 (36%)

8/28 (29%)

3/21 (14%)

Age (yr) C

53.0 (48.1 to 57.9)

43.7 (39.1 to 48.3) §

40.5 (35.7 to 45.4) §§

46.7 (39.4 to 54.1)

  1. ANOVA: A = 10-20; B = 0.042; C = 0.031. [p] = Fisher's Exact test vs. NPasa. Two-tailed, unpaired Student's t-tests: § p = 0.02; §§ p = 0.002 and §§§ p < 2 × 10-5 vs. NPasa; ¶ p = 0.005 and ¶¶ p < 10-13 vs. OMC; † p = 0.005 vs. NPother.