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Table 2 Olfactory epithelial and lung manganese concentrations in young monkeys following exposure to air or MnSO4. Manganese concentrations were determined by graphite furnace atomic absorption spectrometry and are expressed as mean ± SEM μg Mn/g tissue wet weight. Young male rhesus monkeys (n = 4 except where noted) were exposed to either air or MnSO4 6 hours/day, 5 days/week.

From: Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys

Tissue

MnSO4 exposure concentration (mg Mn/m3)

15

33

Exposure Day 65

65 [+45]a

65 [+90]a

Olfactory epithelium

0

  

0.42 ± 0.01b

  
 

0.06

  

1.22 ± 0.15*b

  
 

0.3

  

2.96 ± 0.46*

  
 

1.5

6.10 ± 0.39*

7.34 ± 0.70*

7.10 ± 2.01*

0.65 ± 0.04

0.69 ± 0.11

Lung

0

  

0.15 ± 0.03b

  
 

0.06

  

0.18 ± 0.01b

  
 

0.3

  

0.25 ± 0.02*

  
 

1.5

0.39 ± 0.06*

0.35 ± 0.02*

0.33 ± 0.04*

0.09 ± 0.01

0.06 ± 0.01

  1. a Number in brackets indicates number of days post exposure assessment.
  2. b n = 6.
  3. * p < 0.05
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Respiratory Research

ISSN: 1465-993X

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