Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study

Respiratory Research

Table 2 Incidences and hazard ratios for asthma hospitalisation by intron-8 polythymidine tract and F508del genotype during 24 years follow-up

Poly-T	Expected exon-9 skipping, %	F508del heterozygosity	n	Incidence n/10000 person-years	P-value*	Unadjusted HR (95%CI)	Adjusted^† HR (95%CI)	90% power^‡ HR
9T/9T	7		83	9.8	0.83	1.2 (0.28–4.7)	1.1 (0.27–4.4)	2.7
7T/9T	13		1540	9.3	0.60	1.1 (0.76–1.6)	1.1 (0.77–1.6)	1.4
7T/7T	18		6905	8.4	-	1.0	1.0	-
6T/7T	≥18		4	0	0.77	-	-	15
5T/9T	43		40	10	0.85	1.2 (0.17–8.6)	1.2 (0.17–8.9)	3.7
5T/7T	48		308	5.3	0.35	0.63 (0.23–1.7)	0.53 (0.17–1.7)	1.8
5T/5T	78		2	0	0.84	-	-	25
9T/9T	-	yes	23	0	0.49	-	-	4.9
7T/9T	-	yes	217	11	0.47	1.3 (0.59–3.1)	1.3 (0.55–2.9)	2.0
7T/7T	-	yes	5	87	0.003	11 (1.5–78)	6.3 (0.84–47)	13
5T/9T	-	yes	4	0	0.77	-	-	15

*P-values are for the comparison with 7T/7T individuals without the F508del deletion by log-rank test. ^†Cox regression adjusted for gender, age at study entry, tobacco use during follow-up, and FEV₁ % predicted at study entry. ^‡90% power to detect a hazard ratio (HR) of asthma at 2-sided P < 0.05. 95%CI = 95% confidence interval. Hospitalizations from asthma (ICD8: 493; ICD10: J45–46) were drawn from the Danish National Discharge Register from 1976 through 2000.

ISSN: 1465-993X