Figure 4
From: The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis
Levels of TNF-α in BALF and IL-10 in lung homogenates of SD rats (A-B) and NMRI mice (C-D) after intratracheal instillation of saline or silica particles (2.5 or 25 mg/ g lung). Bars represent means +/- SEM of 5 to 7 animals. Significant differences between treated animals and controls: **P < 0.01, ***P < 0.001 (Student-Newman-Keuls multiple comparison test). At day 3, absolute levels of TNF-α in saline rats and mice were respectively 6.3 ± 0.7 and 11.7 ± 1.2 pg/ml. For IL10, 175.5 ± 1.2 and 3618.1 ± 422.8 pg/ml were respectively detected in saline rats and mice (day 3).