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Table 1 Number of B- and AB-clones displaying hyper- or hyporesponsive IL-8 and IL-6 production to LPS or TNF-α. Clones transfected with E1A plus E1B are designated AB and clones transfected with E1B are designated B. Hyperresponsive and hyporesponsive clones are defined respectively as clones with a significant (p < 0.05) 2.5-fold increased or 2.5-fold decreased (i.e. 0.4 times) IL-8 or IL-6 production relative to the mean of the control (T) clones, for all tested doses of a stimulus.

From: E1A expression dysregulates IL-8 production and suppresses IL-6 production by lung epithelial cells

   Hyperresponsive Hyporesponsive  
   LPS TNF-α LPS TNF-α Total
IL-8 B 0 1 2 2 6
  AB 2 2 0 0 6
IL-6 B 0 0 2 2 6
  AB 0 0 1 3 4