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Table 1 Total and differential cell counts of BAL fluid from p47phox +/+ WT and p47phox -/- KO mice, at day 1 and day 14 after intranasal administration of bleomycin (BLM, 0.1 mg/mouse) or saline vehicle (Control, NaCl 0.9%). Results are presented as the mean (.103cells) ± SEM. n: number of mice. WT: wild-type; KO: knockout; a: P < 0.05, b: P < 0.01, c: P < 0.001 compared with control mice exposed to saline solution only. *: P < 0.05, **: P < 0.01, ***: P < 0.001 for KO mice compared with WT mice.

From: The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis

Treatment

Strain

N

Total Cells

Macrophages

Neutrophils

Eosinophils

Lymphocytes

Control

[WT]

10

540 ± 99

536 ± 97

4 ± 2

0

0

 

[KO]

10

535 ± 105

393 ± 69

129 ± 37 ***

1 ± 1

11 ± 5 **

BLM, day 1

[WT]

8

490 ± 77

317 ± 50

164 ± 28 c

0

0

 

[KO]

9

2208 ± 733 b, e

281 ± 102

1922 ± 634 c, **

0

2 ± 2

BLM, day 14

[WT]

8

1108 ± 80 b

991 ± 77 a

76 ± 15 c

20 ± 6 b

24 ± 13 b

 

[KO]

9

793 ± 118

634 ± 97 a, *

62 ± 12

18 ± 16

80 ± 33 a